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Nat Med: Durvalumab combined with targeted therapy for advanced urothelial cancer

 Last Update: 2021-05-20
 Source: Internet
 Author: User

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Platinum-based chemotherapy is still the most widely used systemic therapy for urothelial carcinoma (AUC).

Devalumab (Durvalumab) is a PD-L1 (programming death ligand 1) inhibitor, and researchers have found that it has clinical activity in advanced AUC.

The study aims to test the safety of durvalumab in combination with one of the three targeted drugs in AUC, and to analyze whether it can improve the clinical activity of the drug.

BISCAY study the efficacy data of different groups

The trial uses a new type of biomarker-driven multi-arm adaptive design, mainly to evaluate the safety, efficacy and related biomarkers of the drug.

Correlation between FGFR mutant ctDNA and treatment response

All in all, the results of this study support the clinical activity of FGFR inhibitors and durvalumab monotherapy, but they have not confirmed the increase in the activity of the combination therapy.

The results of this study support the clinical activity of FGFR inhibitors and durvalumab monotherapy, but have not confirmed the increase in the activity of the combination therapy.

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