Nat Med: Does Tau's molecular diversity make Alzheimer's clinicalhesis?
-
Last Update: 2020-07-14
-
Source: Internet
-
Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit
www.echemi.com
Alzheimer's disease (AD) can lead to sexual cognitive impairment, but its process estoctic, cognitive decline rates range wideexisting studies have shown that the spread of tau aggregates (neural fibrous tangles) throughout the brain is parallel to the severity of symptomsAs a result, the researchers speculate that the dynamics of tau propagation may vary from person to person if the properties of the spreading tau protein are different, the researchers performed biochemical, biophysical, MS, and cell- and animal-based bioactivity assays to characterize tau proteins in 32 AD patientsresearchers found that the high phosphorylation species of soluble, oligomer, and seed-capable tau had significant patient heterogeneityTau seed activity is associated with aggressiveness of clinical diseases, and some post-translational modification (PTM) sites appear to be associated with increased seed activity and poorer clinical results, while some sites are notthese data suggest that different 'typical' AD individuals may have unique tau biochemical characteristicsThese data are consistent with the likelihood that individuals will have AD, and like cancer patients, an otherwise common epitope may have multiple molecular drivers and highlight the advantages of personalized treatments to slow down clinical progression of AD
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
