Nat mat: breakthrough! Researchers first used biomaterials to regenerate functional brain tissue

May 25, 2018 / BIOON / - due to the limited ability of brain regeneration to repair damaged brain tissue, stroke has become one of the main causes of disability After a stroke, the normal brain tissue will be lacking in the stroke area, mainly due to the increase of inflammation and immune response, the severe restriction of angiogenesis and nerve growth At present, therapeutic angiogenesis promoting materials have been used to repair the ischemic site of adult stroke, the main function is to form vascular network However, it is still unclear whether these angiogenic materials can promote nerve repair Photo source: UCLA health researchers from UCLA and Duke University in Tatiana Segura and Thomas to directly help repair brain nerve tissue and promote better recovery of patients Under the leadership of Professor Carmichael, an engineered immune regulatory angiogenesis biomaterial was directly delivered to the stroke site to promote the regeneration of neural tissue They found that this biomaterial can form axonal network accompanying blood vessels in the damaged site, and these regenerated tissues can recover their functions through the existing axonal network Therefore, this method of biomaterials can generate functional neural networks with vascular networks in the dead tissues in the past, which lays a foundation for the use of angiogenic materials to repair the damaged tissues of other neural diseases Reference: Thomas Carmichael et al Dual function inputable angular biological for the repair of brain tissue following stroke, nature materials (2018) Nature.com/articles/doi: 10.1038/s41563-018-0083-8