Nat Genet: scientists have identified a new subtype of malignant pancreatic cancer

January 16, 2020 / BIOON / -- recently, an international magazine published in Nature Genetics In the research report above, scientists from Cancer Research Institute of Ontario, Canada and other institutions have identified new pancreatic cancer subtypes through research, in-depth understanding of the pathogenesis of this type of pancreatic cancer may help to develop new treatments and improve the clinical prognosis of patients with this fatal disease Image source: oicr In this study, the researchers conducted the most comprehensive molecular subtype analysis of pancreatic cancer so far Through detailed genomic and transcriptome analysis, the researchers identified five different subtypes, namely, basal like a subtype, basal like B subtype, typical a subtype, typical B subtype and mixed subtype Each subtype has special molecular characteristics, which may be able to be used in new chemotherapy and biology Target effect of physical and immunotherapy Dr faiyaz notta, researcher, pointed out that because we do not fully understand the molecular subtypes of this fatal disease, the development of treatment for pancreatic cancer has been hindered; through in-depth analysis of malignant pancreatic cancer, researchers may be expected to develop a new disease progress prediction model, and also help to develop a new individualized pancreatic cancer treatment In this paper, the researchers analyzed more than 300 patients with early and malignant pancreatic cancer who were enrolled in the compass clinical trial to develop a new individualized therapy for pancreatic cancer Most pancreatic cancer research focuses on early or resectable tumors, but in fact, patients are diagnosed when pancreatic cancer begins to develop and spread to other organs, the researchers said Patients with this disease; the compass test can help researchers to analyze this cancer while treating patients, and clarify the biological mechanism behind metastatic pancreatic cancer and the reasons for the progress of the disease Interestingly, prior to this study, the researchers found that basal a-subtype pancreatic cancer, which is difficult to observe, is related to special genetic abnormalities; most basal a-subtype tumors All of them contain multiple copies of mutated KRAS gene, i.e genetic amplification of mutated KRAS The researchers hypothesize that some subtypes may be due to special genetic changes, which will occur continuously with the development of pancreatic cancer Finally, researcher Steven gallanger pointed out that this study may provide new clues and ideas for the development of new pancreatic cancer therapy; now we are very looking forward to using the current research results to understand the molecular mechanism of the occurrence of various pancreatic cancer subtypes, so as to lay the foundation for the later development of new personalized therapy Original sources: Chan Seng Yue, M., Kim, J.C., Wilson, G.W et al Transcription phenotype s of pancreatic cancer are driven by genetic events during tumor evolution NAT Genet (2020) doi: 10.1038/s41588-019-0566-9