Nat Commun: Xiamen University Deng early summer team: NOTCH1 activation promotes the formation of triple negative breast cancer
-
Last Update: 2020-07-13
-
Source: Internet
-
Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit
www.echemi.com
Carriers of the BRCA1 mutation have a higher risk of developing triple-negativebreast cancer(TNBC), a refractive disease that does not respond to current clinical targeted therapiesusing the Sleeping Beauty transposonsystem in Brca1 missing mice, the Deng early summer team at Xiamen University identified 169 predicted cancer drivers, including NOTCH1 as the primary candidate to accelerate TNBC by promoting epithelial interstitial transformation (EMT) and regulating cell cyclesactivation of NOTCH1 can suppress fissional fragmentation caused by BRCA1 deletion by activating the ATR-CHK1 signal path and restoring the S/G2 and G2/M cell cycle checkpointsconsistently, analysis of breast cancer tissue in humans showed that NOTCH1 was expressed highly in TNBCs, and that the activation form of NOTCH1 was positively correlated with the increase of phosphorylation of ATR, the researchers demonstrated that inhibition of NOTCH1-ATR-CHK1 works with cisplatin and can be used to kill TNBC in a coordinated way with target cell cycle checkpoints, DNA damage, and EMT, providing an effective clinical option for this deadly disease
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
