Nat Commun: Wang Lidong's team at Zhengzhou University reveals that cardiac cancer in northern China may be related to diet

The Southern Taihang Mountain area at the junction of Henan, Hebei and Shanxi provinces, especially Linzhou (former Linxian) of Henan Province, is the region with the highest incidence and mortality of esophageal cancer and gastric cardia cancer in China and the world
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In 1959, the Henan Provincial Government established an esophageal cancer prevention and treatment team led by Henan Medical College and represented by Professor Shen Qiong, Professor Liu Guiting, and Professor Qiu Songliang, and went to Lin County to carry out multidisciplinary comprehensive prevention and treatment research
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Recently, the State Key Laboratory of Esophageal Cancer Prevention and Treatment was jointly established by Zhengzhou University, the team of Professor Wang Lidong of the First Affiliated Hospital of Zhengzhou University, and the team of Professor Chen Xingqi of Uppsala University in Sweden, and published the title in Nature Communications, a sub-Journal of Nature: Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia denocarcinoma
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This research is contrary to the long-term focus on elucidating the idea of ​​the relationship between nuclear chromatin DNA and tumorigenesis, and found that extrachromatin DNA (ecDNA) located in the cytoplasm is closely related to gastric cardia cancer
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The study found that focal amplification and extrachromatin DNA (ecDNA) frequently occurred in patients with cardia cancer in China, and it was also found that the focal amplification was related to the process of chromosome fragmentation, which may be caused by local eating habits.
Cumulative DNA damage is induced
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The study compared and analyzed the data of whole genome sequencing (WGS) and circle-seq of gastric cardia adenocarcinoma and normal tissues of gastric cardia, and identified extrachromatin DNA (ecDNA) amplicons; confirmed 1/3 The focal amplification was caused by chromosome fragmentation; most of the amplicons identified in WGS were verified by ecDNA sequencing; it was found that all focal amplification fragments only occurred in cancer cells
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The study also found that: there is a positive correlation between the focal amplification of the ERBB2 gene in ecDNA of cardia cancer tissue and the protein expression; analysis of the relationship between the expression of ERBB2 protein and survival in 1688 cases of cardia cancer tissues found that the survival time is greater than 2 years in the cardia Among cancer patients, the survival time of the ERBB2 protein high expression group was significantly better than that of the negative expression group; it was found that the frequency of focal amplification of the ecDNA genome of 28 cases of gastric cardia adenocarcinoma tissue (78%) was very similar to that of esophageal squamous cell carcinoma (80%).
), but is significantly different from distal gastric cancer (50%)
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Professor Wang Lidong, is currently the director of the State Key Laboratory of Esophageal Cancer Prevention and Treatment Co-constructed by the Ministry of Zhengzhou University
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Professor Xingqi Chen, Ph.
D.
graduated from Karolinska Institutet, and completed post-doctoral research at Stanford University
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Dr.

Original source:

Zhao, XK.