Nat Commun: The study reveals the mechanisms of memory formation and maintenance.

September 10, 2020 /--- In a recent study, the University of Bristol made a breakthrough in understanding how memory is formed and maintained.
study, published in the journal nature communications, describes a newly discovered brain learning mechanism that stabilizes memory and reduces interference between them.
its findings also provide new insights into how people form expectations and make accurate predictions about what might happen in the future.
memory is generated when connections between nerve cells that send and receive signals from the brain increase.
has long been associated with stimulating changes in the connections of adjacent nerve cells in the sea mass, an area of the brain that is vital for memory formation.
these excitable connections must be balanced with inhibitory connections to inhibit nerve cell activity in order to achieve healthy brain function.
the effect of changing the intensity of inhibition connections, the researchers found that inhibitory connections between nerve cells could be similarly enhanced.
with computational neuroscientistes at Imperial College London to show how this stabilizes memory.
(Photo Source: www.pixabay.com) their findings reveal for the first time how two different types of inhibitory connections (from neurons that express small albumin and growth inhibitors) can alter and increase their intensity, just like excitatory connections.
addition, computational models show that this inhibitory learning enables the sea horse to stabilize changes in the intensity of excitable connections, thus preventing interference with information from damaging memory.
. Matt Udakis, a research assistant at the School of Physiology, Pharmacology and Neuroscience, said, "We were all very excited when we found that these two types of inhibitory neurons can change their connection and participate in learning.
when we come across a new experience, the memory doesn't go away," he says.
these new findings will help us understand why this is the case.
computer models provide us with important new insights into how inhibiting learning can make memory stable and undisturbed over time.
important because it was not clear how the separated memory remained accurate.
" study was funded by UKRI's Biotechnology and Biological Sciences Research Council, which has provided further funding to the research team to carry out the study and test their predictions based on these findings by measuring the stability of memory symptoms.
, professor of neuroscience at the Synactal Plasticity Center, said: "Memory forms the basis of our expectations for future events and allows us to make more accurate predictions.
constantly doing things that match our expectations with reality.
believe that what we find plays a vital role in evaluating the accuracy of our forecasts and the new information that is therefore important.
.com Source: Research unravels what makesmemories so detailed and enduring Original source: Matt Udakis et al. Interneuron-specific plasticity at parvalbumin and somatostatinory synapses onto CA1 pyramidal neurons shapes hippocampal output, Nature Communications (2020). DOI: 10.1038/s41467-020-18074-8.