Nat Commun: The largest single-cell RNA sequencing project in history! First discovery of glioblastoma stem cells, promising to suppress cancer cells

!---- introduction: glioblastoma is the most malignant glioma in astrocyte tumors, the growth rate is extremely fast, 70% to 80% of patients in 3 to 6 months, the course of the disease more than 1 year only 10%, after active treatment, it is very likely that between six months to a year immediately relapse and rapid progress, therefore, curbing the recurrence of glioblastoma is an important problem to reduce its mortality's deeper understanding of how cancer begins, develops, and becomes resistant to treatment depends in part on a deeper exploration of the biology of cancer stem cellsglioblastoma is the most common adult primary brain cancer, the study of glioblastoma stem cell biology is limitedrecently, a study found a cancer cell structure derived from a single type of cancer cell that can be used to slow the growth of cancer cellsthis study is the largest single cancer cell RNA sequencing project to date, consisting of 55,000 glioblastoma cells and 20,000 normal brain cellsresearchers compared the peline grades of the developing human brain with the transcription group of cancer cellsfound that there were five major cancer cell types in each tumor, similar to those in the brain of a normal human brainsingle-cell RNA sequencing highlights the transcription altruism of glioblastoma and glioblastoma stem cells, researchers first detected what they described as glioblastoma stem cells (GSC), a type of cell from which all other cancer cells developthey showed that the tumor's cell-graded tissue originated from glioma-dry progenitor cellsthe study, published in Nature Communications, entitled "Single-cell RNA-seq reveals glioblastoma re-producing normal levels of neurodevelopment" (Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neuroal hierarchy)researchers wrote in the paper that they have discovered "a conservative neuro-three-line cancer system centered on gliogenic cell-like cells."this progenitor group contains the circulating cells of most cancer cells, and, using RNA velocity, is usually the originator of other cell types"s developmental brain single-cell RNA sequencing and glial protocell identification team found that progenitor gSCs divide more than mature cancer cells, and although they make up the vast majority of the tumor's dividing cells, although they make up a relatively small proportion of the total tumorthese fast-splitting cells are the earliest detectable cancer cells in the hierarchy and thus become promising therapeutic targetsafter identifying the molecular vulnerabilities of the progenitor cells GSCs, the researchers found that the survival and proliferation of progenitor GSCs decreasedin preclinical disease models, this reduces tumor growth and improves survival"Our work has come a long way in addressing the complexity of glioblastoma isoplasis and provides a new framework for rethinking the nature of glioblastoma," said DrKevin Petrecca, a neurosurgeon and brain cancer researcher at the Montreal Institute of Neurology and Hospital at McGill University,as part of this work, our study also showed that, unlike decades of dogma, glioblastoma stem cells are the most rapidly divided cancer cells in tumors, and we have identified new methods for targeting these cellsin the disease, it's not clear how these cancer cells interact with the cancer microenvironment, but this study could serve as a good starting point for understanding how glioblastoma sowmas occur and develop before treatment"fetal brain roadmap shows the three-line structure of glioblastoma centered on protocellular cancer cells, and the team created a hierarchical map that can be used to identify cancer progenitor stem cell-specific therapeutic targetsresearch analysis shows that normal brain development coordinates the development of glioblastoma, suggests possible sources of glioblastoma level, and helps identify specific targets for cancer stem cells