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Nat Commun: The important role and therapeutic potential of PRAK in tumor metastasis

 Last Update: 2021-03-26
 Source: Internet
 Author: User

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Tumor metastasis is a major challenge in the clinical management of cancer .
Approximately 90% of cancer-related deaths are related to tumor metastasis to vital organs.
Although some progress has been made on the molecular basis of metastasis, there is currently no approved therapy for metastasis.

Tumor metastasis is a major challenge in the clinical management of cancer .
Approximately 90% of cancer-related deaths are related to tumor metastasis to vital organs.
Tumor metastasis is a major challenge in the clinical management of cancer .
Approximately 90% of cancer-related deaths are related to tumor metastasis to vital organs.
management

This study revealed the potential selective activity of PRAK in regulating tumor metastasis.
Although it has no significant effect on the growth of primary breast cancer or tumor cell lines inoculated subcutaneously, knocking out Prak can eliminate lung metastasis in PyMT mouse models or mouse models that receive intravenous injection of tumor cells.

Breast cancer

Similarly, the researchers found that the expression of PRAK is closely related to the risk of cancer metastasis.
Further analysis showed that the loss of PRAK function would lead to a significant inhibition of the HIF-1α protein synthesis process, which may be due to the decreased activity of mTORC1.

Knockout of the Prak gene will inhibit the distant metastasis of the tumor but will not affect the growth of the primary tumor

It is worth noting that the pharmacological inactivation of PRAK with clinically relevant inhibitors can reproduce the anti-metastatic effect of knocking out Prak, thus highlighting the therapeutic potential of targeting PRAK in the control of tumor metastasis.

Pharmacological inactivation of PRAK with clinically relevant inhibitors can reproduce the anti-metastatic effect of knocking out Prak, thus highlighting the therapeutic potential of targeting PRAK in controlling tumor metastasis.
Pharmacological inactivation of PRAK with clinically relevant inhibitors can reproduce the anti-metastatic effect of knocking out Prak, thus highlighting the therapeutic potential of targeting PRAK in controlling tumor metastasis.

Original source:

Wang, Y.

, Wang, W.
, Wu, H.

org/10.

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