Nat Commun: Targeted therapy overcomes cancer tolerance.

19, 2020 /--- -- A study led by McGill McGill University published in the journal Nature Communications suggests that inhibiting the OSMR gene can improve the effectiveness of radiation therapy.
new insights into genes that control the energy produced by cancer stem cells could help find more effective treatments for glioblastoma.
the method, developed by the Aarezu Jahani-Asl laboratory, an assistant professor of medicine at McGill University, was successful in preclinical mouse models, where the absence of OSMR genes led to a significant improvement in the response of tumors to treatment and longer life in mice.
(Photo Source: www.pixabay.com) Glioblastoma has become the most common and invasive cancerous brain tumor in adults due to its resistance to treatment.
treatment usually includes surgery, followed by chemotherapy and radiotherapy.
these efforts, in most cases, tumor cells grow again after treatment and the cancer returns.
glioblastoma tumor contains rare cancer stem cells and is key to tumor regeneration and therapeutic resistance.
study, researchers found that OSMR enhances the unique role of cancer stem cells in treatment resistance by enhancing mitochondrials, the power generated by cellular energy.
it takes a long time to reach mitochondrials and interacts with energy-producing machines, forcing them to produce more energy for cancer cells.
to improve patients' response to glioblastoma treatment, we must find new weaknesses in cancer stem cells and overcome their resistance to treatment," said Jahani, a researcher at the center of the study.
by inhibiting OSMR, we can stop the energy production of cancer stem cells and starve them to death.
"s study suggests that the combination of targeted OSMR genes and radiation therapy could pave the way for future clinical trials to better treat glioblastoma tumors.
say the next step is to use these tools in clinical trials.
(bioon.com) Source: Gene targeting overcomes the resistance of brain cancer to the original source: Ahmad Sharanek et al. OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation, Nature Communications (2020). DOI: 10.1038/s41467-020-17885-z.