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News April 23, 2021//---There is still no medicine or vaccine to cure HIV/AIDS, and 37 million people around the world are still infected with HIV
Tissue mononuclear phagocytes (MNP) specialize in pathogen detection and antigen presentation
All MNP subgroups express the key HIV entry receptor CD4, but cDC1 and LC express very low levels of HIV entry co-receptor CCR5, and these two MNP subgroups are also different from other MNP subgroups because they express There are far fewer lectin receptors
DC-SIGN, which binds to HIV, was previously considered a DC marker and was found to be involved in HIV capture and transfer to T cells
These authors further observed that all CD14-expressing cells (hereinafter referred to as CD14+ cells) subpopulations can take up HIV efficiently, but MDDC take up significantly more HIV
These authors also found that MDDC expresses higher levels of CCR5 than other CD14+ cell populations.
Recently, it has been found that cDC2 located under the epithelium exists in the epidermis of human anogenital skin tissues.
In summary, these authors found that HIV can cross the epithelial surface and interact with the subepithelial MNP of anal-genital explants, and identified human anal-genital tissues and colon tissues that HIV may encounter during sexual transmission.
Reference materials:
References:
Jake W.
Rhodes et al.
Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells .
Nature Communications, 2021, doi:10.
1038/s41467-021-22375-x.
Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
