Nat Commun: Scientists are hoping to develop new treatments for malaria.

11, 2020 // In a recent study published in the international journal Nature Communications, scientists from the Australian National University and others have developed a new treatment to treat malaria, which is resistant to drugs, and that it also enhances the therapeutic effectiveness of current drugs.
image source: Australian National University malaria is caused by the malaria parasite, mainly through the bite of infected mosquitoes to humans, the researchers say, the malaria parasite is evolving to develop some resistance to current drugs, which may be a major threat to effective control and elimination of malaria, in the article, the researchers focused on a protein called PfCRT, which is critical to the generation of malaria parasite strains, but also a potential new drug target. 'For nearly 20 years, scientists from around the world have been delving into the function of pfCRT proteins and why they are critical to the survival of the malaria parasite,' said Martin, a researcher at
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researchers say the pfCRT protein can be suppressed by drugs, suggesting that the natural function of PfCRT may be a potential target for drug development, and could also help develop new treatments that clarify the function of the PfCRT protein or help researchers develop new therapies that effectively block the protein's function and inhibit the spread of malaria.
in addition to directly killing malaria parasites, these targeted drugs can also be used in combination therapy to eliminate the multiple resistance induced by the PfCRT protein and restore the activity of existing drugs.
the treatment of malaria parasites targeted in a variety of ways is critical to effectively combating the spread of multi-drug-resistant malaria; researchers are now able to gain insight into the reasons and constraints that determine the evolution of PfCRT proteins in different malaria-endemic regions of the world; and the latest global malaria report shows that there will be 228 million malaria patients worldwide in 2018 and about 405,000 people will die from malaria infections, forcing scientists to develop in-depth research to combat malaria treatments.
() Originals: Shafik, S.H., Cobbold, S.A., Barkat, K. et al. The natural function of the malaria-up's chloroquine resistance transporter. Nat Commun 11, 3922 (2020). doi: 10.1038/s41467-020-17781-6.