Nat Commun: Revealing the molecular mechanisms of toxic tau proteinspread in the brains of Alzheimer's patients

, June 5, 2020 /PRNewswire/ -- The toxic form of the tau protein is often thought to induce the death of neurons in the brain of Alzheimer's patients, according to a recent study published in the international journal
nature communications, a study published in the international journal nature communications, by scientists from the University of Lund Ander and other institutions found that the spread of toxic tau proteins in the brain in the elderly population may be linked to neurons, while beta-amyloid proteins promote the spread of the proteinPicture Source: Wikipedia/domain
In the paper, the researchers revealed the molecular mechanism by which toxic tau proteins spread in the human brain; researcher Jacob Vogel said, toxic tau proteins spread across different brain regions through direct neuronal connections, much like infectious diseases spreading to other sites through different transport pathways;the results of this study are important because they can help develop new therapies that effectively block the spread of tau proteins and slow the progression of Alzheimer's disease; beta amyloid and tau proteins are thought to be associated with the onset of Alzheimer's disease, which forms plaques in the brain, and tau proteins that form tangles in brain cells, after researchers believed that the spread of toxic tau proteins is linked to degeneration of the brain and symptoms such as memory damagescientists are currently working on a number of studies to reveal the spread mechanism of toxic tau protein in the brain so that new therapies can be developed later to block the spread and progression of the disease, and ongoingclinical trialsare also assessing whether antibodies developed can bind to tau proteins and block the progression of the diseaseFinally, the researchers say that the results of this paper are important for understanding the pathogenesis of disease and are also expected to help develop new treatments for Alzheimer's disease, namely, targeting tau protein or beta amyloid proteinIn addition, treatments that limit neuronal intake of tau protein or limit the transport and excretion of the protein may be expected to inhibit the progression of Alzheimer's disease(BioValleyBioon.com)original origins:Vogel, J.W., Iturria-Medina, Y., Strandberg, O.Tet al.
Spread of the disease tau protein sings through the neurons in human Alzheimer's disease .
Nat Commun 11, 2612 (2020) doi: 10.1038/s41467-020-15701-2