Nat commun: new research reveals the cause of brain damage in stroke! A new stroke drug is on the way!

March 16, 2018 / bioin / - new research reveals how a new drug qnz-46 can help alleviate the effects of brain over release of glutamate (the main cause of brain damage caused by stroke) Photo source: the University of Plymouth study, published in nature communications, showed how they found the source of harmful glutamate caused by stroke, and thus found the brain protective agent qnz-46, a new preventive drug with potential for clinical application This exciting study shows that blood supply first contributes to the release of excess glutamate Glutamate binds to receptors and over stimulates them, leading to the destruction of myelin, the protective layer around axon nerve fibers Past studies have focused on the gray matter of the brain, where all synapses work And this study focuses on the white matter of the brain, the part of the brain that connects all the gray matter, suggesting that glutamate released by axons themselves causes myelin damage The study, led by Professor Robert fern of the Peninsula School of medicine and the school of Dentistry (pupsmd) at the University of Plymouth, is the first to directly compare the process of vesicular fusion between different cell components in the white matter The study shows that there are also a large number of fusion phenomena in the axons - which were previously thought not to exist in the white matter These findings suggest that patients at risk of stroke and other excitotoxic injury (injury caused by excessive glutamate) can be protected with low-intensity prophylactic therapies such as qnz-46 Stroke is the second leading cause of disability and early death in the UK Professor fern reveals the significance of the study "Stroke can lead to a lack of blood supply to the brain, and there is no way to treat the disease at present." He said "Rehabilitation is effective, but you can't do anything to repair the wound That's why we have to look at the way that stroke first causes damage " "Myelin damage leads to severe functional defects in the white matter of the brain, such as ischemic stroke By revealing how this process occurs, we found that qnz-46 can be used to prevent this damage " "Although further research is needed to fully understand how these findings can be further transformed, it is a good signal that no side effects have been observed at this stage Through further research, we may be able to find better drugs to help treat stroke " Reference: Sean Doyle et al Vascular glutamate release from central axes contributions to myelin damage, nature communications (2018) Doi: 10.1038/s41467-018-03427-1