Nat Commun: Neutral granulocytes or promote tumor cell death, but that may not be a good thing

'We looked at the causes of tissue death in necrosis, and scientists believe that hypoxia caused by insufficient blood supply due to rapid tumor growth could lead to cell necrosis,' said researcher Wei Li, who investigated the molecular processes that induce tissue death.
glioblastoma patients with higher levels of necrosis tend to have lower survival rates, and researchers hope to delve deeper into the molecular mechanisms that drive tissue death to help develop new therapies that improve the prognosis of survival for these cancer patients.
photo source: Penn State College of Medicine Researchers say ferroptosis is a particular type of regulatory cell death that induces tissue death.
paper, the researchers analyzed tumor tissue samples from animal models of glioblastoma under a microscope.
found that called neutral granulocytes and white blood cells appear to be in the same tissue region as dead tumor cells.
to clarify whether these cells were part of the tissue death process, the researchers reduced levels of neogenic granulocytes in the animal model body, which in turn reduced the level of necrotic death in the cancer model body.
the researchers isolated the white blood cells and tested their ability to fight cancer cells in the lab, finding that the presence of neutral granulocytes could block the survival of cancer cells. 'By evaluating data from patients with glioblastoma to reveal the key role that neoblastoma plays in tissue necrosis, we confirm our theory that the presence of genetic signals of large numbers of nexual granulocytes and iron death is directly related to pathological evidence of necrosis, and can also help predict poor survival in patients,' said li, a
researcher.
Although the researchers better understood the key factors driving tissue death, they were not sure why it was beneficial to tumor progression; then they studied data sets in patients with glioblastoma and found that dead cells were able to secrete special molecular signals to help tumor cells grow.
The researchers note that more in-depth studies will be conducted later to analyze how white blood cells that stimulate tissue death reach tumors, and they speculate that tissue damage from tumor growth may induce neutral granulocytes to reach tumor tissue, but further research is needed to confirm this.
will continue to explore ways to understand how cell necrotasia promotes cancer growth.
if they can develop a new treatment to curb cell death, it may be possible to make tumors less invasive, which may help better treat glioblastoma patients.
original source: Patricia P. Yee, Yiju Wei, Soo-Yeon Kim, et al. Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression, Nature Communications (2020). DOI:10.1038/s41467-020-19193-y。