Nat commun: natural protein can be used to design anti-cancer vaccine

Nano vaccine has made some achievements in cancer treatment, but its clinical application is still limited due to mass production and quality control problems Recently, researchers from NIBIB have developed a new technology that combines nano vaccines with natural albumin, which can transport nano complexes into lymph nodes and induce antitumor immune response in mice This breakthrough provides a new idea for the clinical application of nano vaccine   One of the two components is responsible for delivering the vaccine to the right location, that is, lymph nodes, while the other part can activate the activity of immune cells, so that they can target the tumor to produce immune response   The authors of the study, postdoctoral research institute from NIBIB, said the technology allows albumin to deliver vaccines directly to lymph nodes, reducing barriers to drug delivery Because mass production and quality control are the speed limiting steps of nano vaccine technology, this technology can accelerate the promotion of nano vaccine technology to clinical direction The results were published in the latest issue of nature communications   At present, some nano vaccines have been designed, each of which carries special antigen molecules In addition, there is a dye called Evans blue in the vaccine, which can bind to the albumin in the body In addition, the vaccine also contains small segments of DNA molecules, which act as a "danger signal" to stimulate the immune cell response, thus making the immune response more intense   In one study, mice were immunized with the vaccines, three times in total, two weeks apart After 70 days, the immunized sales received an injection of tumor cells The results showed that 5 out of 7 mice could reach the survival period of more than 4 months After the five mice were vaccinated again, the survival time of four mice was extended to six months   In conclusion, the author believes that this new vaccine design can greatly promote the clinical transformation of nano vaccine.