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Nat Commun: miRNA scoring system predicts the risk of colorectal cancer

 Last Update: 2021-10-10
 Source: Internet
 Author: User

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Colorectal cancer (CRC) is the world's third most common cancer and the second largest cause of cancer-related deaths.

Although the fecal hemoglobin immunochemical test has proven to be an effective and usable non-invasive test that can be used to screen for the risk of CRC, its sensitivity for detecting advanced adenoma or stage I CRC is limited

Immune screening

Previous studies have shown that the level of microRNA (miRNA) in the blood is related to the occurrence and development of CRC

The level of microRNA (miRNA) in the blood is related to the occurrence and development of CRC

Participant screening related flowchart

In this study, the researchers derived a blood-based miRNA scoring system and evaluated its ability to predict the occurrence and development of CRC in adults aged 50-75

CRC risk prediction

The researchers constructed a 7-miRNA scoring system through logistic regression and evaluated the predictive ability of the system, with an AUC value of 0.

A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction

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