Nat Commun: Men have a three-fold higher risk of COVID-19 sepsis than women

December 10, 2020 // -- According to a recent study, men infected with COVID-19 are three times more likely than women to need intensive care and have a significantly higher risk of death.
researchers analyzed more than 3 million confirmed cases of coronavirus from 46 countries and 44 states in the United States between January 1 and June 1, 2020.
found that men and women had the same risk of sars-Cov-2 infection because "exactly half" of the confirmed cases were male.
men in intensive care units are three times more likely than women to die from the virus and 39 percent more likely to die from the virus, according to the study ( Photo: www.pixabay.com)
data may help doctors recognize that gender is a risk factor for the severity of the disease when managing patients," said Kate Webb, co-author of the study.
University of Cape Town researchers said: "In many studies, the gender variable is under-regarded, which reminds us that gender is an important consideration in the study.
the authors: "There are gender differences between the congenital and adaptive immune systems, which may explain women's strengths in COVID-19.
" women naturally produce more type I interferon proteins, which limit the abnormal immune response of the "cytokine storm", which play a role in triggering COVID-19 severity.
"female" esodiol hormone can also help women fight serious viral infections because it enhances the response of T cells that kill infected cells and increases antibody production, the study said.
, the male sex hormone testosterone suppresses the immune system," the authors note.
," they wrote in a study published in Nature Communications, gender-based differences in severe COVID-19-related complications may put men at greater risk.
, the authors note that worldwide, the ratio of men to women with high blood pressure and diabetes is similar, the most common complication among hospitalized COVID-19 patients.
the findings could have implications for future vaccines, the authors said.
() Source: Men with COVID-19 three times more likely to need intensive care: Study Original Source: Hannah Peckham et al. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission, Nature Communications (2020). DOI: 10.1038/s41467-020-19741-6。