Nat Commun: lncRNA MaTAR25 affects the development of breast cancer by regulating the Tns1 gene

Breast cancer is one of the most common cancers among women in the United States and around the world, with about 276,480 new indension cases in the United States by 2020.
the overall mortality rate from breast cancer has declined year by year over the past two decades, it remains the second leading cause of cancer death among women in the United States.
42,170 people are expected to die from the disease by 2020, or 15 percent of all cancer deaths between women, according to the National Cancer Institute.
Breast Cancer can be divided into subtypes based on histological assessment, the most common being catheterized cancer, which can be further divided into two groups: breast catheter in place (DCIS) and immersive catheterized cancer (IDC), accounting for 75% of all breast cancers.
In addition to traditional pathological characterization and immunologicalization (IHC) analysis, which can detect protein levels of markers such as ER (estrogen-like, PR(progesterone-like) and HER2 (skin growth factor-infested 2), other studies that assess genomic recombination and molecular expression provide further genetic insights into the development of breast cancer.
recent years, large-scale genome-wide studies have shown that genomes that lack protein coding capabilities can transply thousands of RNAs.
increasing number of studies have shown ≥ non-coding RNA (lncRNA) with a length of 200 nucleotides plays a vital role in a variety of biological processes.
and the wrong regulation of lncRNA is also associated with the occurrence of a variety of cancers.
In the study, researchers found that MaTAR25 (breast cancer-related RNA 25), a nuclearally rich and chromatin-related lncRNA, plays an important role in the proliferation, migration, and invasion of breast cancer cells.
MaTAR25 works by interacting with PURB, mediates its main downstream target gene Tns1 (Tensin1) and regulates its trans expression.
protein encoded by Tns1 is an important component of the adhesive spot that connects the signaling between the extracellular substation and the cytostic skeleton.
knock-out of MaTAR25 can cause Tns1 expression to decrease, leading to the recombination of the cytostic skeleton, as well as a decrease in sticky spots and micro fluff.
further studies have shown that LINC01271 is a direct human-origin 1st-origin 1st-origin 1st-origin 1st-origin 1st-origin 1st-origin 1st-origin 1st- and, more importantly, that elevated expression of LINC01271 is associated with poor prognostic and tumor metastasis in patients.
the expression of LINC01271 in breast cancer and pulmonary metastasis tumors, the results reveal that MaTAR25 and its human-origin orthytoiser LINC01271 may be potential therapeutic targets that affect the development of breast cancer.
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