Nat commun: Living conditions determine our susceptibility to disease, junk food can "detonate" negative effects

On June 16, Beijing's emergency response level was raised from three to twoTherefore, from kindergarten to college students, and many active employees have to live a home at homeDuring this period, in addition to pay attention to do a good job of personal protection, we must pay attention to the environment and food healthAll home at home, don't eat junk fooda recent study published in Nature Communications showed that living conditions have a profound effect on the development of organs early in life, affecting metabolic function, determining susceptibility to disease throughout life, and even intergenerational effectsepigenome scants are sometimes referred to as "software" or "operating systems" of the genome, which refer to the chemical modification of chromosomal DNA and proteins, which regulate the activity of all genesearly in life, the epigenome changes with our normal developmentIn this process, exposure to endocrine-disrupting chemicals (EDC, also known as environmental hormones) leads to extensive reprogramming of "software"EDC is a chemical that interferes with the endocrine system by external sourcesDepending on the organs, the reprogrammed vulnerability window can occur at any time, from uterine development to childhood and adolescence, depending on how long normal development lastsProfessor Cheryl Walker,research author and director of the Baylor School of Medicine's Center forPrecisionenvironmental health, said: "In this study, we found that even brief exposure to endocrine-disrupting chemicals in the liver accelerates the aging of the epigenome of the liver during liver developmentthe study showed that early exposure to EDC can lead to metabolic dysfunction in adulthood and reprogram histone markers in the developing liver to accelerate the acquisition of epigenome characteristics in adulthoodthis epigenetic reprogramming persists long after initial exposure, many reprogrammed genes remain silent on transcription, and their effects on metabolism are not apparent until they are exposed to Western diets as adultsDietary-dependent metabolic disorders are mainly driven by the reprogramming of the early growth reaction 1 (EGR1) transcription group and the production of metabolites incholesterol, lipids, and monocarbon metabolic pathwaysin a healthy liver, the epigenome goes through a normal aging processBut in rat models exposed to EDC, the researchers found that the process was acceleratedIt gives a 6-day-old rat the same epigenome as an adult ratPhoto: Nature CommunicationsProfessorWalker: "The effect of this change on metabolic function is not immediate, but rather is like a time bomb, only when we change animals to a western diet high in fat, sugar and high cholesterolThe study,, found that rats exposed to EDC early and late-stage Western diets were more likely to experience metabolic dysfunction than those exposed to the same EDC but on a healthy dietAlthough their epigenomes have been reprogrammed, those who maintained a healthy diet did not show the same changes as those on a high-fat, high-sugar and high-cholesterol diet in terms of gene expression or lipid accumulation in the serum that controlled metabolismPhoto: ProfessorWalker,Nature Communications, said: "This study shows how environmental exposure affects our health and susceptibility to disease, both early and late in lifeThis also shows that some adults who experience environmental exposure in their early years may be more likely to be adversely affected by a high-fat diet than others "