Nat Commun: Liver perfusion improves the effectiveness of the donor liver.

, June 19, 2020 /PRNewswire/ -- Biovalley BIOON/--- According to a recent study, the authors found that liver perfusion can be an effective way to improve donor liver functionThe results were published in the latest issue of Nature Communicationschronic liver disease caused by obesity and alcohol abuse is on the rise every year in the UK, killing around 8,500 people each yearFor those with advanced liver disease, transplantation is the only hope of survival, but the demand for a suitable liver far exceeds the supplyCurrently, one third of donor livers in the UK do not meet the required transplant criteria and cannot be used(picture:most of the livers, which are of lower quality and pose a risk to recipients of income, cannot be transplanted because more and more people in liver donors are suffering from alcoholism or obesityexperts at the University of Birmingham's Centre for Liver and Gastroenterology, University Hospitals Birmingham NHS Foundation Trust and NIHR Birmingham Biomedical Research Centre, funded by the Wellcome Trust, found that a four-to-six-hour machine perfusion assessment could restore 70 per cent of the livers currently in need of discarded to a level that is successfully transplanted into the recipientProfessor Darius Mirza, director of theVITTAL project and consultant transplant surgery at Birmingham NHS Foundation Trust University Hospital, added: "This challenging study aims to assess the ability of the donor liver to repair using normal body temperature perfusion techniquesDr Simon Afford, of the Department of Liver Immunobiology at the University of Birmingham's Institute of Immunology and Immunotherapy, said: "
It has long been recognized that the quality of donated livers has been declining as a result of an ageing populationBased on our latest findings, we believe that in the near future, the machine perfusion platform will contribute to therapeutic interventions that improve liver viability, and we hope to be able to effectively repair the liver in more than 70% of VITTAL trials"(Bio Valley Bioon.com)source:Study surveys effectiveness of the liver perfusion to the function of the thethe function of the livers
original source: Mergental, H., et al (2020) The Sauerd of the of the Nature Communications doi.org/10.1038/s41467-020-16251-3.
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