-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Responsibility Editor | Enzymatic instinctive behaviors, such as feeding, mating, fighting, predation, etc.
, are the basis for animal survival and reproduction
.
These behaviors are solidified by evolution, and can respond quickly to external stimuli, ensuring that the instinctive behavior is fast and stable
.
However, instinctive behaviors also need to be adjusted in real time according to the environment when responding to complex environmental stimuli to ensure that the behavior is flexible
.
On November 11, 2021, Nature Communications published online research results of the collaboration between the research group of Professor Li Haohong of Zhejiang University (formerly working at Wuhan National Research Center for Optoelectronics) and the research group of Professor Wei Shen of Shanghai University of Science and Technology: Periaqueductal Gray Neurons Encode the Sequential Motor Program in Hunting Behavior of Mice
.
The research team clarified for the first time the basic law of the predation behavior of animals encoded by the neurons of the aqueductal gray (Lateral periaqueductal gray, LPAG)
.
The study found that LPAG neurons form multiple electrical activity clusters that control predation actions and encode various modules in the behavior process; then these predation instruction modules form more advanced sequence instructions to guide the action sequence of predation behavior
.
The advantage of this encoding method is that it not only ensures the accuracy and stability of the action output, but also ensures the flexibility of the animal to respond to changes in the external environment, thereby increasing the success rate of animal predation
.
The way the neuron sequence is encoded is crucial to the generation of behavior
.
Previous studies have found that in the process of learning, memory and decision-making, the brain's hippocampal structure and motor cortex neurons plan target paths and form target-oriented actions in a sequence of firing activity patterns
.
However, it remains to be determined whether similar coding mechanisms are used in instinctive behaviors, such as predation
.
The study used in vivo multi-channel recording, photoelectrode recording and optogenetic manipulation techniques to clarify its specific neural mechanisms
.
Multi-channel recording experiments show that the six neuron clusters in LPAG respectively encode the search, tracking and attack phases of predation in a strict time sequence
.
Photoelectrode recording and optogenetic inhibition experiments show that the LPADVgat neuron cluster controls the predation search, chase and attack phases, while the LPAVglut2 neuron cluster regulates the predation attack phase
.
Schematic diagram of the motion sequence of LPAG encoding predation behavior.
Previous studies have shown that multiple upstream brain regions of PAG are related to predation behavior
.
Subsequently, the study used loop-specific apoptosis combined with multi-channel recording technology to analyze how LPAG neuronal clusters process neural signal inputs from different sources
.
The study found that blocking GABAergic input from the central amygdala (Central amygdala, CeA), lateral hypothalamus (LH), and indeterminate zone (Zona incerta, ZI) affects the activity of different LPAG neuron clusters and destroys The timing of neuron firing will affect predation behavior
.
All in all, the study reveals the mechanism by which LPAG neuron clusters encode predation sequences, providing an example of decoding complex instinctive behaviors
.
Dr.
Yu Hong, Dr.
Xiang Xinkuan and Dr.
Chen Zongming are the co-first authors of the article, and Professor Li Haohong and Professor Shen Wei are the co-corresponding authors
.
Article link https:// Platemaker: Notes for reprinting on the 11th [Non-original article] The copyright of this article belongs to the author of the article.
Personal forwarding and sharing are welcome.
Reprinting is prohibited without permission , The author has all legal rights, and offenders must be investigated
.
, are the basis for animal survival and reproduction
.
These behaviors are solidified by evolution, and can respond quickly to external stimuli, ensuring that the instinctive behavior is fast and stable
.
However, instinctive behaviors also need to be adjusted in real time according to the environment when responding to complex environmental stimuli to ensure that the behavior is flexible
.
On November 11, 2021, Nature Communications published online research results of the collaboration between the research group of Professor Li Haohong of Zhejiang University (formerly working at Wuhan National Research Center for Optoelectronics) and the research group of Professor Wei Shen of Shanghai University of Science and Technology: Periaqueductal Gray Neurons Encode the Sequential Motor Program in Hunting Behavior of Mice
.
The research team clarified for the first time the basic law of the predation behavior of animals encoded by the neurons of the aqueductal gray (Lateral periaqueductal gray, LPAG)
.
The study found that LPAG neurons form multiple electrical activity clusters that control predation actions and encode various modules in the behavior process; then these predation instruction modules form more advanced sequence instructions to guide the action sequence of predation behavior
.
The advantage of this encoding method is that it not only ensures the accuracy and stability of the action output, but also ensures the flexibility of the animal to respond to changes in the external environment, thereby increasing the success rate of animal predation
.
The way the neuron sequence is encoded is crucial to the generation of behavior
.
Previous studies have found that in the process of learning, memory and decision-making, the brain's hippocampal structure and motor cortex neurons plan target paths and form target-oriented actions in a sequence of firing activity patterns
.
However, it remains to be determined whether similar coding mechanisms are used in instinctive behaviors, such as predation
.
The study used in vivo multi-channel recording, photoelectrode recording and optogenetic manipulation techniques to clarify its specific neural mechanisms
.
Multi-channel recording experiments show that the six neuron clusters in LPAG respectively encode the search, tracking and attack phases of predation in a strict time sequence
.
Photoelectrode recording and optogenetic inhibition experiments show that the LPADVgat neuron cluster controls the predation search, chase and attack phases, while the LPAVglut2 neuron cluster regulates the predation attack phase
.
Schematic diagram of the motion sequence of LPAG encoding predation behavior.
Previous studies have shown that multiple upstream brain regions of PAG are related to predation behavior
.
Subsequently, the study used loop-specific apoptosis combined with multi-channel recording technology to analyze how LPAG neuronal clusters process neural signal inputs from different sources
.
The study found that blocking GABAergic input from the central amygdala (Central amygdala, CeA), lateral hypothalamus (LH), and indeterminate zone (Zona incerta, ZI) affects the activity of different LPAG neuron clusters and destroys The timing of neuron firing will affect predation behavior
.
All in all, the study reveals the mechanism by which LPAG neuron clusters encode predation sequences, providing an example of decoding complex instinctive behaviors
.
Dr.
Yu Hong, Dr.
Xiang Xinkuan and Dr.
Chen Zongming are the co-first authors of the article, and Professor Li Haohong and Professor Shen Wei are the co-corresponding authors
.
Article link https:// Platemaker: Notes for reprinting on the 11th [Non-original article] The copyright of this article belongs to the author of the article.
Personal forwarding and sharing are welcome.
Reprinting is prohibited without permission , The author has all legal rights, and offenders must be investigated
.
