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Nat Commun: Intraciliary transport decreases with age, impairing sensation and metabolism

 Last Update: 2021-03-30
 Source: Internet
 Author: User

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It is currently known that sensory perception and metabolic homeostasis will deteriorate with age, thereby damaging the health of elderly animals, but the mechanism of its deterioration is still poorly understood.

They reported that due to the reduction of IFT components regulated by daf-19/RFX , the intrafellar transport (IFT) of sensory neurons in elderly nematodes was impaired.

Since Since DAF-.

The enhanced sensory perception up-regulates AMPK activity through par-4 and octopamine .

The study found that the starting point of the sensory circuit - sensory cilia dysfunction is the main reason for the decline in sensory ability due to aging .

Feeling starting point circuit feeling starting point of the circuit - - sensory cilia dysfunction in aging is the main cause of reduced ability to feel the sensation of cilia dysfunction caused by aging is the main reason for the decline in sensory abilities with age, with age Increase, IFT IFT gene’s main transcription factor gene’s main transcription factor DAF-19/RFX DAF-19/RFX decreases, down-regulation decreases, down-regulates IFT IFT components, destroys multi-protein components, destroys multi-protein IFT IFT complexes, and reduces The complex in the sensory cilia reduces the IFT IFT in the sensory cilia , thereby impairing sensation.

Improve sensory perception and promote the healthy survival of worms.

In aging worms, feeling the cilia in the aging worms, feeling the cilia in IFT IFT reduction weakens the sense of perception, and, above all by reducing weakened in sensation, and first through PAR-4 / LKB1 PAR-4 / LKB1 feeling Regulation in neurons regulates AMPK AMPK signals in sensory neurons , and then regulates signals in other tissues such as the intestine, and further regulates AMPK AMPK signals in other tissues such as the intestine .

Cilia are important regulators of cell survival and function.

Zhang, Yincong et al.

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