Nat commun: high dose Zika virus vaccine can protect mother and baby at the same time

December 17, 2019 / Biovalley BIOON / -- medical researchers at the University of Texas Galveston have shown for the first time that a single higher dose vaccination of pregnant mice can safely protect her and her fetus from Zika virus infection The results were published in nature communications "Prevention of natural defects in development is an important goal of Zika virus vaccine, but there is a lack of research on vaccination for pregnant women, which raises many important questions, such as: can vaccination during pregnancy prevent infection and spread to the fetus? Will pregnancy affect the immune response of Zika vaccine? Can vaccination immunity of pregnant women during pregnancy prevent neonatal infection? These issues are critical to the clinical development and regulatory approval of Zika vaccines " Pei Yong Shi, the author of the article, said (image source: www Pixabay Com) Shi and his lab have developed Zika vaccine before, and continue research to improve its efficacy In addition to protecting mothers and babies, the researchers also learned that their live attenuated vaccines are extremely safe in pregnant mothers and fetuses, Shi said For example, they believe there is no adverse effect on pregnancy, fetal development or infant behavior They also found that pregnancy weakened the mother's immune response to the vaccine, suggesting that higher doses or more immunogenic vaccines were needed during pregnancy Together, their results show that both pregnant and non pregnant women can consider using their vaccines 资讯出处： Zika vaccine protects both mom and fetus, but mom needs a higher dose when pregnant 原始出处： hao Shan, Xuping Xie, Huanle Luo, Antonio E Muruato, Yang Liu, Maki Wakamiya, Jun-Ho La, Jin Mo Chung, Scott C Weaver, Tian Wang, Pei-Yong Shi Maternal vaccination and protective immunity against Zika virus vertical transmission Nature Communications , 2019; 10 (1) DOI: 10.1038/s41467-019-13589-1