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Nat Commun: Giving two peptides through the nose is expected to slow the progression of Parkinson's disease

 Last Update: 2021-10-11
 Source: Internet
 Author: User

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In a new study, researchers from the Rush University Medical Center in the United States have made new progress in the treatment of Parkinson’s disease: the potential new treatment for Parkinson’s disease they developed has shown to slow the progression of the disease in mice.

Specifically, the authors found that two different peptides help slow the spread of alpha-synuclein, an abnormal protein deposit called Lewy body in the brain.

Lewy bodies are also related to dementia with Lewy bodies and a rare neurological disease---multiple system atrophy (MSA)

The activation of NF-κB increases the expression of α-synuclein in neurons

The two peptides tested in this new study are called Myd88's TLR2 interaction domain (TLR2-interacting domain, TIDM) and NEMO-binding domain (NEMO-binding domain, NBD)

Note: The original text has been deleted

Reference materials:

Debashis Dutta et al.

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