Nat Commun: Diet may affect the gut microbiome of the host body and thus the effectiveness of cancer therapy

, June 7, 2020 /AP/BiovalleyBIOON/ -- In a recent study published in the international journalNature Communications, scientists from the University of Virginia and others have shown that, like many other therapies, what we eat affects the prognosis of chemotherapy because it is a chain reaction that begins in the gut;Photo Credit: Dan Addison, University CommunicationsThis study opens up a new dimension of medical research that is essential for effectively predicting the right dose of chemotherapy and controlling side effects, as well as helping scientists explain differences in chemotherapy responses between different patients, said elien O'Rourke, who found for the first time in the study that changing the gut microbiome or adding a single amino acid to a diet could turn harmless doses of drugs into highly toxic drugsBy screening hundreds of microbes and host genes, the researchers found that there may be a complex association between diet, microbes, drugs and hostsclinicians have long recognized the importance of nutrition for the health of the body, but this study highlights that the food we eat affects not only ourselves, but also the organisms of the bodyChanges in the diet's induced body microbes increase the toxicity of chemotherapy drugs to 100 times, and in the paper, researchers studying a new model of laboratory nematodes, and found that adding a milligram of serine to the diet may kill nematodes at the same dose of drugs that do not have any effect on the dietin addition, different diets and microbial combinations can alter the host's response to chemotherapy, and the results suggest that a single dietary change may alter the metabolism of microorganisms and may even reverse the host body's response to drugs; There are more than 0 kinds of microbes that we feed in a way that may have a profound impact on the health of the body and the body's response to therapy; (BioValleyBioon.com)original origins:Ke, W., Saba, J.A., Yao, Cet al.
Dietary serine-microbiota interaction sriseutic toxicity without altering drug.
Nat Commun 11, 2587 (2020) doi: 10.1038/s41467-020-16220-w