Nat Commun: Develop new ways to synthesize natural compounds against cancer!

July 24, 2020 /PRNewswire/ -- Plant antitoxins are a class of bioactive phytochemicals that have attracted widespread attention in recent years and have the role of promoting human and plant healthChemists at the Technical University of Dresden have developed a new and very effective synthesis method for these substancesWith this new approach, they are paving the way for simpler production of plant antitoxins, thus paving the way for large-scale investigations into their effects, particularly their positive impact on cancerThrough a balanced diet, we consume large amounts of plant antitoxins every day in a natural and healthy wayPlant antitoxins are a phytochemical that plants react to certain stimuli to maintain their healthNumerous scientific studies have shown that these biologically active natural products also have a health-promoting effect on humansHowever, in order to study its mechanisms in more detail, it is important to simply acquire individual plant antitoxins, which have so far been inefficient and have been used with toxic substancesPhoto: DrPhilipp Ciesielski and Professor Peter Metz, I, I, Technical University of Dresden, Germany, proposed a new and efficient method of plant antitoxin synthesis in the prestigious Nature Communications journalIn particular, low-level synthetic plant antitoxin syin antitoxin I and soy antitoxin II -- a substance produced by a portion of the immune response in soybean plants, is a decisive innovationThese two natural compounds have a wide range of biological activities, including antitumor activity and health, antioxidant and anti-cholesterol effectsPrevious soy antitoxin I and soybean antitoxin II synthesis used a large number of highly toxic and expensive oxidants as well as a large number of expensive accessories as ligands in key stepsThe newly proposed synthetic route does not require thorium tetraoxide and proves to be more efficient"Our way of synthesizing various plant antitoxins makes it easier for us to get these substances," says Prof MetzThis is an important basis for further study of the biological activity of these natural compounds and may also provide a basis for their further development as therapeutic drugsThe pathways to the basic structure of plant antitoxins described can also be used by other research groups for the synthesis of related natural and active compoundsReferences: Philipp Ciesielski et alAsymmetric one-pot change of isoflavones to pterocarpans and its application in phytoalexin synthesis, Nature Communications (2020)DOI: 10.1038/s41467-020-16933-y.