Nat commun: breakthrough! Targeting these 11 metastasis promoting genes can completely inhibit the metastasis of cancer cells

June 26, 2018 / BIOON / - metastasis is the most lethal cause of cancer, but the current treatment strategy cannot target its speed limit steps In the past, we know that the ability of tumor cells to enter the blood (also known as infiltration) is highly dependent on the movement ability of tumor cells, which makes this process become an attractive anti-tumor target Photo source: Melissa Fabrizio in order to systematically study the genes that affect the movement ability of tumor cells in the tumor microenvironment in vivo, researchers from the Department of oncology of University of Alberta and other units established a new platform for in vivo quantitative screening of metastasis related genes based on in vivo imaging of human tumor metastasis in chicken embryo The related research results were recently published in nature In communications, it is entitled "quantitative in vivo whole genome mobility screen changes new thermal targets to block cancer metastasis" By using this platform to screen the whole tumor genome shRNA library, the researchers found a series of genes necessary to maintain the ability of tumor cells to move in vivo The expression of these genes is closely related to the risk of human tumor metastasis By using RNAi technology to inhibit the expression of these genes, the researchers almost completely (> 99.5%) inhibited the transient metastasis of tumor in vivo In general, this study found the necessary gene targets in the key steps of tumor metastasis, which will bring new ideas to prevent, diagnose and treat tumor metastasis Reference: Konstantin stoletov et al, quantitative in vivo whole genome mobility screen reviews new thermal targets to block cancer metadata, nature communications (2018) Doi: 10.1038/s41467-018-04743-2