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Nat Commun: BCMA/CS1 bispecific CAR can prevent antigen escape during CAR-T treatment of MM

 Last Update: 2021-05-20
 Source: Internet
 Author: User

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Chimeric antigen receptor (CAR)-T cell therapy has shown significant clinical effects on B-cell malignant tumors, but there are defects in antigen escape and tumor recurrence.

CAR-T

Heterogeneous multiple myeloma (MM) that is resistant to B cell maturation antigen (BCMA) traditional CAR-T cell therapy has strong activity, and the results of the study have been published in Nat Commun.

The results showed that, compared with T cells expressing a single BCMA and CS1 CARs simultaneously, BCMA/CS1 bispecific CAR-T cells showed excellent CAR expression and function.

In summary, BCMA/CS1 bispecific CAR is a promising treatment method to prevent antigen escape when CAR-T cells treat MM.

Original source:

Eugenia Zah, et al.

ncbi.
nlm.
nih.
gov/32385241/" target="_blank" rel="noopener">Systematically optimized BCMA / CS1 bispecific CAR- T cells robustly control heterogeneous multiple myeloma

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