Nat Commun: A meta-analysis study of brain and nervous system activities related to placebo analgesia

Placebo has an important contribution to the treatment results of patients in both medical research and clinical practice.
Therefore, a better understanding of its underlying mechanisms is important for optimizing drug development and clinical care.

Placebo has an important contribution to the treatment results of patients in both medical research and clinical practice.
Therefore, a better understanding of its underlying mechanisms is important for optimizing drug development and clinical care.
Placebo has an important contribution to the treatment results of patients in both medical research and clinical practice.
Therefore, a better understanding of its underlying mechanisms is important for optimizing drug development and clinical care.

Placebo analgesia is the most effective and the best type of placebo effect in the current study.
More and more neuroimaging studies have clarified the brain relevance of placebo analgesia.
These studies and the meta-analysis of findings also provide relevant evidence for the study of brain regions related to pain processing, including early pain control mechanisms, and other forms of learning and social cognition related to healthy behaviors.
However, there is insufficient research on the brain system related to placebo analgesia.

In this study, researchers conducted a systematic meta-analysis of experimental functional neuroimaging studies of induced pain under placebo and controlled treatments with matching stimulus intensity.
The analysis included 20 studies (28 eligible in total).
Study) 603 healthy participants.

The researchers conducted a systematic meta-analysis of experimental functional neuroimaging studies on induced pain under placebo and controlled treatments with matching stimulus intensity.
The analysis included 603 from 20 studies (28 eligible studies in total) Healthy participants.
The researchers conducted a systematic meta-analysis of experimental functional neuroimaging studies on induced pain under placebo and controlled treatments with matching stimulus intensity.
The analysis included 603 from 20 studies (28 eligible studies in total) Healthy participants.

Pain-related activities in an experimental placebo imaging study

Researchers found that placebo and control treatments can cause a reduction in the range of pain-related activities, especially in the ventral attention network (including mid-insula) and body motor network (including posterior insula) areas.
Further research has shown that behavioral placebo analgesia is associated with reduced pain-related activities in these networks, as well as in the thalamus, habenula, cingulate tract, and auxiliary motor areas.
The placebo-related increase in activity mainly occurred in the parietal area, and the heterogeneity between studies was high.

Placebo-induced changes in pain-related activities

All in all, the results of the study reveal that placebo treatment affects pain-related activities in multiple brain regions, which may reflect changes in nociceptive pain and/or other emotional and decision-making processes surrounding pain.
The heterogeneity between the above studies also shows that placebo analgesia is a phenomenon involving multiple brain mechanisms.

Placebo treatment affects pain-related activity in multiple brain regions, which may reflect changes in nociceptive pain and/or other emotional and decision-making processes surrounding pain.
Placebo treatment affects pain-related activity in multiple brain regions, which may reflect changes in nociceptive pain and/or other emotional and decision-making processes surrounding pain.

Original source:

Zunhammer, M.

, Spisák, T.
, Wager, TD et al.

org/10.

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