Nat Commu: Cerebral vascular abnormalities caused by stroke are associated with gut bacteria.

, June 19, 2020 /PRNewswire/
-- In a nationwide study, NIH-funded researchers found that abnormally brittle blood vessel beams in the brain or spinal cord are associated with the composition of bacterialthe human gut, known as spongiform hemangioma (CA)These lesions, also known as brain spongy malformations, contain slow-moving or stagnant blood and usually cause hemorrhagicstrokes
, epilepsy, or headachesCurrent treatment includes surgical removal of diseased blood vessels in safe conditionsPrevious studies in mice and a small number of patients have shown a link between CA and gutbacterialThe study is the first to examine the possible role of gut microbes in a larger CA patient populationphoto source: Awad Lab University of Chicago, ILLed by scientists at the University of Chicago, researchers used advanced genomic analysis techniques to compare stool samples from 122 people with at least one CA with age and gender matching, and controlled non-CA participants, including samples collected through the American Gut ProjectAt first, they found that CA patients had more Gram-negative bacteria on average, and the control group had more Gram-positive bacteria, and that CA patients could be distinguished from the control group based on the relative abundance of the three gut bacteria, regardless of a person's gender, geographic location orgeneticsusceptibilityIn addition, the gutbacteria from CA patients
appears to produce more lipid polysaccharides molecules that have been shown to drive the formation of CA in miceAccording to the authors, these results are the first to prove in humans a "microbiome" associated with the formation of nerve vascular damage in the brainfurther analysisshowed that some gut bacteria could identify invasive and non-invasive diseases, as well as recent bleedings with symptomsThey also showed for the first time how to combine gut bacterial data with plasma test results to help doctors betterdiagnose the severity ofbrain diseaseThe study, published in Nature Communications, supports growing evidence that the gutbacteriaon brain health(BioValleyBioon.com)reference:Sean PPolster et al.
Permissive microbio simees human subjects with a neurovascular disease cavernous angioma , Communications Nature (2020) DOI: 10.1038/s41467-020-16436-w
.