Nat cell biol: Ladies, please note that cosmetology may really work

February 17, 2020 / Biovalley BIOON / -- biologists at University of Manchester first explain what a good night's sleep can prepare us for the next day A study of mice, published in the journal Nature Cell Biology, reveals how the clock mechanism improves our ability to maintain our bodies when we are most active Professor Karl Kadler, the lead author of the study, believes that the discovery may one day help to solve some of the mysteries of aging because we know that the body's biological clock will become less accurate as we grow older Photo source: https://cn.bing.com this discovery has aroused interest in human extracellular matrix Extracellular matrix provides structural and biochemical support for cells in the form of connective tissue such as bone, skin, tendon and cartilage More than half of our body weight is matrix, and half of it is collagen - scientists have long known that when we were 17 years old, it was fully formed But now researchers have found that there are two types of fibers - the rope like structure of collagen woven from cells The thicker fibrils, about 200 nanometers in diameter, are 1 million times smaller than needles, are permanent, and have remained unchanged since we were 17 years old But they found that 50 nanometers of filaments are sacrificed When our bodies are subjected to severe tests during the day, the filaments break, and when we rest at night, the filaments are replenished The researchers found that when the mouse clock gene was knocked out, thin and thick fibers were randomly combined Professor Kadler said: "collagen provides structure for the body, is our most abundant protein, ensuring the integrity, elasticity and strength of the body's connective tissue We instinctively think our mother body should be worn, but it's not Now we know why: our biological clock makes an element that can be sacrificed and supplemented to protect another part of the body So, if you think of the bricks on the walls of a room as permanent parts, the paint on the walls can be seen as sacrificial parts that need to be added frequently Just as you need to refuel your car and fill the radiator with water, these thin fibers help maintain the body's matrix Understanding this may have an impact on our understanding of the most fundamental aspects of biology For example, it may give us a deeper understanding of how wounds heal, or how we age Reference: Joan Chang et al Circular control of the secret pathway maintains colon homeostasis, Nature Cell Biology (2020) Doi: 10.1038/s41556-019-0441-z