Nat Cell Biol: Cancer cells cause inflammation to protect themselves from viral infections

, June 7, 2020 /PRNewswire/
-- Researchers at the Francis Crick Institute have found how cancer cells protect themselves from viruses that are harmful
totumors but are not harmful to healthy cellsThese findings may improve the treatment of the virus for the diseasein their study, published in the journal NatureCell Biology, researchers found a mechanism that protects cancer cells from the solute virus, which prioritizes infection and kills cancer cellsthese viruses are sometimes used as a treatment to destroy cancer cells and stimulate an immune response totumorsHowever, they only work in a small number of patients, and it is not entirely clear why they are effectivePhoto Source: ni-
research team examined the surrounding scarcity oftumorsand how cancer cells interact with the surrounding cells, especially cancer-related fibroblasts (CAFs), which the researchers know play an important role in the protection, growth and spread of cancerthey found that when cancer cells come into direct contact with CAFs, they cause an inflammatory response that warns surrounding tissue and makes it harder for the virus to invade cancer cells and replicate within themthis protective inflammatory response occurs when cancer cells deliver a small amount of cytoplasm (the fluid inside the cell) to CAFs This triggers fibroblasts to signal to nearby cells, releasing cytokines, the molecules that cause inflammation "This process only happens if cancer cells come into direct contact with fibroblasts," said Study author and group leader Erik Sahai of the Cancer Cell Biology Laboratory at University of In healthy tissue, this inflammatory response only occurs when injured, as they are usually separated by a layer of film This is a great example of cancer hijacking our physical protection mechanisms for their own benefit "
important, when researchers blocked signaling pathways in cell culture and laboratory-grown tumor , they found that cancer cells became more sensitive to the tumor virus they hope the findings will help develop a treatment that regulates inflammation in the future, helping the tumor virus attack cancer cells more effectively "If we can get a fuller picture of tumors cells protect themselves from sooviruses and find effective ways to stop these protections, these viruses could become a more powerful tool that doctors can use to treat cancer," said Emma Milford, a ph.d.i student at the Cell Biology Laboratory, the study The study is an important early step in that direction Antonio Rullan, a clinical researcher at the Oncology Cell Biology Laboratory, added: "These viruses prefer to attack cancer cells rather than healthy cells, which have been of interest to scientists over the past few decades However, there is much to be learned about how they interact with tumor and immune system "
researchers plan to continue this work and study how cytoplasm is transferred from one cell to another (BioValleyBioon.com) References: Cancer Cells Sons for The Project to Protectthemlyvirus from the of StING and IRF3 in stromalblasts, the yn seision stod siton in cancer cells to the sacroon colytic viral theviral virus, Nature Celly (2020) DOI: 10.1038/s41556-020-0527-7 ,