Nat Cell Biol: Blood vessels can sense the metabolic state of surrounding nerve cells

June 18, 2020 /PRNewswire/ -- Bio Valley BIOON/--- brain is our most energy-intensive and metabolically active organIt is responsible for our thoughts, ideas, movements and abilities to learnour brains are powered by 600 kilometers of blood vessels that provide nutrients and remove wasteIn addition, because the brain is so fragile, the blood vessels in the brain have evolved into a close protective barrier, the blood-brain barrierThis barrier effectively limits the transfer of molecules inside and outside the brainOn the one hand, pathogens or toxins can be effectively prevented from entering the brain, but on the other hand, the required messengers or nutrients can pass unhindered(Photo:The latest work in the Asifa Akhtar laboratory shows that blood vessels can sense the metabolic state of surrounding nerve cellsresearchers found that the epigenetic regulator MOF is necessary for neurons to be equipped with the correct metabolic enzymes needed to process fatty acidsWhen MOF's activity is defective (as in neurodevelopmental disorders), neurons are unable to metabolize fatty acids properly, which causes them to accumulate in gaps between brain cellsteam found that this imbalance in fatty acids can be perceived by nerve blood vessels, stimulating them to stimulate stress by relaxing the blood-brain barrierIf metabolic imbalance persists, the leaking blood-brain barrier can cause diseasestudy provides a better understanding of how nerve cells and blood vessels interact with each other in the brain and sheds light on how changes in the metabolic environment of a cell type in complex organs directly affect the function of surrounding cells and, in turn, the function of surrounding cellsOverall organ function"Our work shows that proper metabolism in the brain is critical to their healthPoor neurometabolic environment induces vascular inflammation, forming a blood-brain barrier of cell dysfunction and increased permeabilityA nervous blood vessel rupture ensued," Asifa Akhtar explained (Bio Valley Bioon.com) source: Blood vessels smosense the tha cica ness of the country of the sauer-sau, study shows
original source: Sheikh, B N., et al (2020) neural lyops by MOFem
s Nature Cell Biology.
doi.org/10.1038/s41556-020-0526-8.