Nat Cell Bio: Mysterious protein found in patients with advanced breast cancer that could be used to treat breast cancer

Introduction: The cause of breast cancer is not yet clear, early breast cancer often does not have typical symptoms and signs, not easy to attract attention, but the incidence of breast cancer is the first in women's malignant tumors, so women often talk about color changeEarly detection and early diagnosis of breast cancer is the key to improve the efficacyScientists in South Australia recently discovered a Creld2 protein that hijacks normal cells and promotes tumor growth and spread, blocking the protein, which is a key topic of research and is expected to stop the growth and spread of breast cancerbreast cancer is often referred to as the "pink killer", the incidence of the first female malignancyAccording to the latest data from the International Agency for Research on Cancer (IARC) survey in 2018, breast cancer is the highest incidence of cancer in women worldwide at 24.2 per cent, with 52.9 per cent occurring in developing countriesin China, the incidence of breast cancer is increasing year by year, more than 300,000 women are diagnosed with breast cancer every yearThe rise in breast cancer rates is particularly pronounced in the eastern coastal areas and in the economically developed major citiesFrom the age of onset, the incidence of breast cancer in China began to rise gradually after the age of 20, reaching a high value between 45 and 50 years oldWith the popularization of new treatment strategies and methods, the global mortality rate from breast cancer is decreasingsouth Australian scientists have made a major breakthrough in discovering how an obscure protein causes breast cancer to develop and grow rapidlyand lead scientist DrMarina Kochetkova, senior UniSa researcher at the Center for Cancer Biology (CCB), who led the study, said a highly expressed protein called Creld2 is associated with the most invasive breast cancer, which causes lower survival rates for breast cancerthe study, published May 26 in Nature Cell Biology, describes how invasive breast cancer produces Creld2, which in turn hijacks healthy cells to promote tumor progression"Scientists have been identifying this protein for some time, but they haven't studied it yet, and we haven't known what it plays in breast cancer until now," Samuel saidCreld2 appears to cause normal, healthy cells around the tumor to behave abnormally, which in turn helps the tumor growThe CCB team, a coalition of the University of South Australia and the South Australian Pathology Institute, is currently focusing on destroying or blocking the treatment of Creld2 in order to stop the growth and spread of breast cancer in the body found high-expression Creld2 in triple-negative breast cancer, which accounts for 15 percent of all breast cancers in Australia, is difficult to treat and has a low survival rate and is common in young women breast cancer is closely related to the development stage of the disease, the earlier the disease is detected, the better the patient's chances of survival within five years According to the International Cancer Organization statistics, the five-year relative survival rate of breast cancer patients is 89.9%, of which the five-year survival rate of in situ cancer is 98.8%, the five-year survival rate of early-dip cancer is 85.5%, and the five-year survival rate of distant metastasis of leaching cancer is only 27.4% Creld2 has also been found in kidney cancer, non-melanoma skin cancer (the most commonly diagnosed cancer in Australia) and invasive squamous cell carcinoma These cancers could be fatal if not detected early the prognosis of these cancers is poor, and if researchers can find a cure to destroy or block the protein, it could potentially stop the growth and spread of the tumor