NAT CELL BIO: Liver cell aging secretions promote tumor development
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Last Update: 2020-06-05
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Source: Internet
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Author: User
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To date, we are not fully aware of the interaction between liver cell metabolic disorders and cells in the tumor microenvironment, as well as the effects on liver tumorsrecently, researchers found that the absence of hepatocellular-specific glycoenzyme 1,6-bphophosphinase 1 (FBP1) disrupts the metabolic balance of the liver and promotes tumor progressionFBP1 is widespread in human and mouse liver tumorsthe absence of liver cell-specific Fbp1 can lead to degreasing liver cells, accompanied by the activation and aging of hepatic astrocytes (HSCs), showing the secretion phenotypes associated with agingThe death of aging HSCs by treating 'senolytics' such as dasatinibini or ABT-263 can inhibit the progression of the tumorfurther evidence by researchers that FBP1-defective liver cells promote HSC activation by releasing HMGB1Blocking its release with a small molecule, inflachromene, can limit The activation of HSCs that are FBP1-dependent, and subsequent aging-related secretion phenotypes and tumor progressionoverall, these findings provide genetic evidence of FBP1 as a metabolic tumor inhibitor for liver cancer and establish a critical series relationship between liver cell metabolism and HSC aging to promote tumor growth
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