Nat Aging: Scientists have the potential to map senescent cells in the body and their effects on aging and health

Recently, a study entitled "NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health" published in the international journal Nature Aging, Scientists from Jackson Laboratory and other institutions in the United States have drawn a map of senescent cells and their impact on aging and human health through research
.

In the article, the researchers focused on the body's senescent cells, which can stop dividing in response to stress, which seems to play a very important role in human health and the aging process, and recent studies in mice have shown that clearing senescent cells in their bodies may slow the occurrence of age-related abnormalities and diseases, while also reducing all-cause mortality
.

So can therapeutic treatments called senotherapeutics remove senescent cells improve the health problems that occur as the body ages? Answering this question and the many more questions it raises may greatly improve human health, so researchers at the NIH in the United States have launched a broad research program
.
The SenNet Research Consortium, founded in 2021, has established a research center that collects and analyzes human data, and researchers will collect and analyze 18 tissues from healthy people across their lifespan to analyze the full range of senescent cells and how they contribute to the aging process
.

Scientists are expected to map senescent cells and their effects on aging and health
.

Image source: Nature Aging (2022).
DOI:10.
1038/s43587-022-00326-5

In the article, the researchers analyzed the tissues related to the occurrence of chronic diseases of aging in the body, such as senescent cells from the kidneys, placenta, pancreas and heart; They will also use mouse models of their genetic diversity, including diverse outbred population mice, to simulate a range of molecular aging characteristics, and visually analyze
senescent cell populations through specially engineered mice.

Since the three tissues (kidney, placenta and pancreas) from the Mouse Aging Tissue Atlas Center (JAX-Sen TMC) can share some information with the Human Aging Tissue Atlas Center, and the related research is consistent with the original intention of researchers to continue to build the human-mouse interface, the purpose of the establishment of the body's aging network is not only to establish the blueprint of senescent cells in the body and understand the biological characteristics of senescent cells; Researchers are excited about the potential benefits of ageing therapeutics for healthy aging in humans, and there may be other possible clinical applications, such as helping to identify specific populations at high risk of age-related diseases
.
(Biovalley Bioon.
com)

Original source:

SenNet Consortium.
 NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.
 Nat Aging 2, 1090–1100 (2022).
doi：10.
1038/s43587-022-00326-5