Nanoparticles promote resveratrol stability and biological utilization (foodaily)

Researchers in Portugal have used a nano-carrier system to protect resveratrol from photodegradation in a simpler and more economical way, while improving resveratrol's ability to pass through the intestinal barrier and promote absorption.University of Porto recently reported on two carrier systems, solid lipid nanoparticles (
SLNs
) and nanostructure lipid carriers (
NLCs
), which can be used well in dietary supplements and nutritional care products."SLNs
and
NLCs
are biodegradable and biomass compatible lipids that are certified as safe by
FDA
and can be combined with resveratrol, which is highly oil-averse, water-soluble and will be widely used in dietary supplements in the future.

"
in addition, the preparation of lipid nanoparticles is very simple, fast and economical,"
Nutrients
wrote.
”Resveratrol resveratrol is a polyphenol widely found in grapes and wines with very good biological activity,
In
2003, Harvard
David Sinclair
and his team first discovered that resveratrol can extend the life of yeast cells. The study, published
the
Ofure, was quickly reprinted in the world's media and sparked a frenzy over anti-aging pills.based on research by the
Sinclair
team, resveratrol activates the deacetylase
1
gene (
Sirt 1
, transcriptions of
Sirt 2
) in yeast, and activation of this gene has also been found in various energy-restricting animal models, including monkey models.other studies have found that resveratrol has anti-cancer, anti-inflammatory, cardiovascular health, anti-diabetes, increased energy tolerance, and the prevention of Alzheimer's disease.carrier systemUniversity of Porto found that oral resveratrol had some difficulty. Resveratrol is less water-soluble, rapidly hydrolysed after entering the body, and is quickly metabolized. In addition, trans resveratrol is a biological isomer that is sensitive to light and quickly transforms into a smooth structure (less biologically active).previous studies have used a variety of methods to try to maintain the stability of resveratrol and promote absorption. A new report describes two potentially effective nanosystructures that can be used in dietary supplements and functional foods and beverages.SLNs
is an alternative to water-soluble solid lipid xenonyl palmate,
NLCs
to select solid lipid hexaane palmate and liquid lipid
Miglycol-812
. Resveratrol has a encase rate of
80%
,
"
suggests that both carrier systems can be used for oral resveratrol.
,"
researchers said.the nanosysms can also reduce the photosensitivity of resveratrol, the researchers added.experiments with gastrointestinal environment simulations,
NLCs
increased the intestinal wall pass rate of resveratrol, while
SLNs
did not affect resveratrol absorption.based on the results, the researchers recommend that people use the product at meal time. When eating, the intestinal fluid secretes and increases resveratrol's ability to pass through the intestines. "SLNs
and
NLCs
have been shown to protect the structural stability and intestinal ability of trans resveratrol. These two lipid nanoparticles are able to maintain good compatibility with resveratrol after oral use, thus improving the efficiency of resveratrol utilization in the body.
”