Nano polypeptides for delivery of chemotherapy drugs

Researchers at Duke University in the United States have developed a simple and cheap method to transport anticancer drugs to the corresponding target through a nano vehicle When the drugs are transported to the corresponding tumor site, the nano vehicle will automatically decompose into non toxic by-products of patients The research report was collected by medical education network and published in the recent journal Nature materials Compared with the normal blood vessels, the tumor blood vessels are porous The anticancer drugs transported by the nano delivery system can enter the tumor efficiently and accumulate in the tumor cells to kill the tumor cells Therefore, in recent years, the nano delivery system has attracted more and more researchers' attention The delivery system is a kind of special artificial polypeptide, chimeric polypeptide, which is produced by genetically modified Escherichia coli Most anticancer drugs can not be dissolved in water, so the absorption of the drug by cells is limited, but the anticancer drugs and the chimeric polypeptide are placed in the same container, they can self assemble into a stable water-soluble nanoparticles, and the size is about 50 nm, so they are the ideal choice for cancer treatment The researchers chose adriamycin, an anticancer drug commonly used to treat breast cancer and ovarian cancer, to study They injected the combination of adriamycin and chimeric polypeptide into the subcutaneous of mice transplanted with tumor In addition, the researchers injected adriamycin alone into the subcutaneous of mice transplanted with tumor as the control group The results showed that the tumor of mice collected by adriamycin alone was 25 times larger than that of mice using adriamycin chimeric peptide complex, and the average survival time of the former was 27 days, and the average survival time of the latter was more than 66 days At present, the researchers intend to test the new combination for different types of cancer, and try to combine this kind of chimeric peptide with other insoluble drugs to test its anti-tumor effect.