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Nano Letters: Peking University makes progress in tumor nanovaccine research!

 Last Update: 2022-04-24
 Source: Internet
 Author: User

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Recently, the academic journal Nano Letters published online the latest research results of Wang Yiguang's research team from the State Key Laboratory of Natural and Biomimetic Medicine, School of Pharmacy, Peking University, "A pH-/enzyme-responsive nanoparticle selectively targets endosomal Toll-like receptors to potentiate robust cancer vaccination.

Wang Yiguang's pH/enzyme-programmed responsive Toll-like receptors selectively target smart tumor nanovaccine

In the treatment of malignant tumors, immunotherapy represented by immune checkpoint inhibitors, tumor vaccines, etc.

Among them, Toll-like receptor (TLR) agonists can be used as excellent adjuvants for tumor vaccines.

Currently, it can only be administered clinically in external dosage forms such as emulsions and gels, and the scope of application is severely limited

Wang Yiguang's research team designed a smart tumor nanovaccine (TLR activating nanovaccine, TNV) based on Toll-like receptor agonism based on the existing pH-sensitive (Ultra-pH-sensitive, UPS) nanotechnology platform of the research group.

In the nanovaccine TNV, the TLR7/8 agonist IMDQ was covalently bound to the hydrophobic block of the UPS polymer through an enzyme-sensitive bond GFLG, and formed nanomicelles through cooperative self-assembly

Researcher Wang Yiguang of Peking University School of Pharmacy is the corresponding author of this research paper

Original link:

https://pubs.

https://pubs.
acs.
org/doi/10.
1021/acs.
nanolett.
2c00185.

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