MYC2 is a high-level transcription control element in the jasmine acid signal path.

Jasmine acid is a plant immune hormone derived from unsaturated fatty acids, and its biosynthetic pathways and chemical structure are highly similar to the immune hormone prosthetics in higher animals.
In the case of mechanical injuries, chewy insects, and dead-body nutrient pathogens, plants activate the jasmine signaling path, initiate and cascading amplifying the transcription reprogramming of jasmine mediated, resulting in an effective defensive response.
little is known about the process by which jasmine acid activates plant immune transcription reprogramming.
Chuanyou research group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has long used tomatoes as a model plant to study the molecular mechanism of jasmine acid to regulate plant immunity.
A recent study by the research team found that MYC2, the core transcription factor of the jasmine acid signaling pathway, achieves effective protection against disease and insect attack by positively regulating the expression of genes related to mechanical damage and disease-related genes that are closely related to disease resistance.
Using a combination of chromatin immuno-precipitation-sequencing (ChIP-Seq) and genome-wide expression spectrum-sequencing (RNA-Seq), the Li Chuanyou team identified a series of target genes for direct myC2 binding throughout the tomato genome.
interestingly, the team found that the target gene directly binding to MYC2 was rich in transcription factor genes, indicating that MYC2 is a high-level transcription regulatory element in the jasmine acid signaling path.
further studies show that MYC2 and its directly combined secondary transcription factor form a series of transcription cascading regulation modules.
these transcription cascading regulation modules play a vital role in the activation and cascading amplification of immunothrem reprogramming.
this finding is of great significance for people to understand the mechanism of jasmine acid regulation plant disease resistance and insect resistance, and provides important theoretical guidance for the molecular breeding of tomato disease resistance and insect resistance.
the findings were published online July 21 in The Plant Cell (DOI: 10.1105/tpc.16.00953).
, Ph.D., of Li Chuanyou Research Group, and Zhao Kuhai, professor at Shandong Agricultural University, are co-authors of the paper.
research was funded by the Chinese Academy of Sciences, the Ministry of Science and Technology, the Ministry of Agriculture and the National Natural Science Foundation of China.
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