my country's pesticide formulations are accelerating the upgrading and enhancing the international market competitiveness

On April 21-22, 2016, the "Fifth Environmentally Friendly Pesticide Preparation Processing Technology and Production Equipment Seminar" sponsored by China Pesticide Industry Association was held in Wuxi, a resort on the shore of Taihu Lake
.
The conference was sponsored by the China Pesticide Industry Association and co-sponsored by Jiangsu Tom Packaging Machinery Co.
, Ltd.
, a leading company in the field of pesticide packaging machinery manufacturing in China.
Jiangsu Qingyu Chemical Technology Co.
, Ltd.
was the first sponsor
.
The meeting invited leaders and experts from the Pesticide Inspection Institute of the Ministry of Agriculture, Shanghai Pesticide Research Institute, and China Agricultural University.
At the same time, it attracted more than 800 representatives from domestic and foreign pesticides and related fields.
The meeting was an unprecedented grand occasion
.
The theme of this conference is "safety, environmental protection, ecology, refinement"
.
The purpose of the conference is to exchange the development trends of domestic and international pesticide preparations processing, discuss the hot and difficult issues in the processing of pesticide preparations in China, guide the development of preparations processing in China in the direction of "safety, environmental protection, ecology, and refinement", and accelerate the upgrading and improvement of the pesticide preparation industry in China.
Pesticide preparation processing level and international competitiveness
.
The meeting was first chaired by Secretary-General Li Zhonghua of China Pesticide Industry Association
.
She pointed out that with the rapid development of China's pesticide industry, Chinese pesticide companies are facing increased pressure on environmental protection and safety, overcapacity, and prominent homogeneity competition.
In 2015, the benefits of the entire industry declined.
The Ministry last year put forward China's goal of zero growth of pesticides and fertilizers in 2020.
All of this has caused Chinese pesticide manufacturers to face unprecedented challenges
.
How to improve the quality of pesticides and provide products that farmers are satisfied with are all issues facing Chinese pesticide manufacturers
.
Chairman Sun Shubao of China Pesticide Industry Association delivered a speech for this conference
.
Chairman Sun pointed out that in recent years, the processing of pesticide preparations in China has developed rapidly and made great progress
.
In 2014, the main formulations of pesticide preparations were made domestically, and the export of pesticide preparations surpassed the export of original medicines for the first time
.
However, my country’s formulation processing is small and scattered, the processing technology and equipment are backward, the level of automation is low, the working conditions are poor, the cost of additives is high, the formulation of the formulation is extensive, and the overall level is still not high.
The situation still needs to be changed.

.
In recent years, the market and policies have jointly driven the transformation of pesticide preparation processing technology to efficient, environmentally friendly, and environmentally friendly green manufacturing
.
In terms of the market, the rapid development of flying defenses, the use of large-scale pesticide application equipment, and unified defense control have all put forward new requirements on pesticide formulations and packaging, and promoted the industrial upgrading of formulation processing
.
In terms of policy driving, the state has proposed the policy goal of achieving zero growth in the application of pesticides and fertilizers in China by 2020; the upcoming "Pesticide Industry Air Pollutant Emission Standards" puts forward strict requirements on the emission of dust and harmful gases in production; Ministry of Environmental Protection The draft of the "Administrative Measures for Recycling and Disposal of Pesticide Packaging Waste" has been published
.
All this will promote the development of formulation processing technology in a highly efficient, environmentally friendly and environmentally friendly direction
.
In recent years, environmentally friendly water-based formulations such as suspensions, water emulsions, and physical formulations of large granules have become more and more in the proportion of pesticide formulations.
Water, fertilizer and medicine are integrated, and seed dressing and coating agents have developed rapidly.
The formulation of relevant standards has been put on the agenda
.
Chairman Sun called on companies interested in the improvement and transformation of green pesticide formulation processing technology to participate in the formulation of standards, thereby leading the trend of green, environmentally friendly and environmentally friendly pesticide processing technology and forming a new pesticide formulation processing model
.
Mr.
Tang Jianhua, Chairman and President of Jiangsu Tom Machinery Co.
, Ltd.
, the co-sponsor of the Harmonious Tom, Benefits and Win-win Conference, delivered a keynote speech with the theme of "Harmonious Tom, Benefits and Win-win"
.
After nearly 20 years of development, Tom Group has now become a benchmark enterprise in the field of pesticide packaging machinery manufacturing with a total of more than 1,800 domestic customers and more than 300 foreign agrochemical customers, with sales all over the world
.
Among the top 100 pesticide manufacturers in China, 96, and well-known domestic and foreign pesticide companies Syngenta, Bayer, Nopson, Tianyuan, Huifeng, Fengshan, Kesheng, etc.
have all become Tom's strategic partners
.
In 2015, under the sluggish situation of China's manufacturing industry, Tom Group seized the market, gave full play to its scale, quality, and brand advantages, and achieved sales of 248 million yuan
.
Steady growth in market sales
.
Tom Group leads the new trend in the development of pesticide formulations packaging, and innovatively launched the two concepts of "seven chemicals workshop" and "seven properties equipment" to help China's pesticide formulation processing industry innovate and upgrade
.
"Seven Chemical Workshop" is a comprehensive workshop integrating seven services of "specialization, safety, environmental protection, intelligence, integration, information and efficiency"
.
"Seven-character equipment" is a new equipment concept that integrates the seven requirements of "advancedness, accuracy, adjustability, high efficiency, economy, stability, and aesthetics"
.
"Seven Chemical Workshop" and "Seven Characters Equipment" are the embodiment of the unique craftsman feelings of Tom people who constantly innovate, strive for perfection, and pursue the ultimate pursuit
.
Under the guidance of this concept, the operation of Tom’s customer’s packaging workshop will become simpler, the staff will be streamlined, the environment will be tidy, and the workshop production will become safer and more efficient
.
Post-registration evaluation and development trend of pesticides Zong Fulin, Director of the Pesticide Inspection Institute of the Ministry of Agriculture, gave a report entitled "Post-registration evaluation and development trend of pesticides", which systematically introduced the background, current situation and development ideas of pesticide registration management in China
.
In recent years, China's pesticide registration has grown rapidly, and post-registration management of pesticides will also focus on the safety and effectiveness of pesticide registration
.
Strengthening the post-registration management of pesticides mainly lies in strengthening systematic monitoring and special research, building and broadening the pesticide withdrawal mechanism, and strengthening the research and evaluation of re-evaluation of pesticide varieties
.
This year, we will advance the risk re-assessment of 8 pesticide varieties including triazophos, atrazine, imidacloprid, methachlor, sulfachlor, alachlor and butachlor, and promote the implementation of the prohibition and management of highly toxic pesticides
.
Director Zong introduced in detail the development of pesticide registration in China in recent years and the management of pesticide registration at home and abroad
.
From 2011 to 2015, my country's pesticide registration has developed rapidly.
The number of registered products has increased from more than 29,000 in 2011 to 34,315 in 2015.
There are 661 active ingredients registered, 2,232 companies, and 30,269 preparations.
A
.
Products in an effective state: 12,932 insecticides, accounting for 37.
7%; 8,569 fungicides, accounting for 25.
0%; 8,012 herbicides, accounting for 23.
3%.
The registration of formulations has grown rapidly and officially registered Beyond temporary registration, the speed of formal registration of preparations is much faster than that of technical registration
.
Regarding post-registration management, Director Zong introduced that the United States initiated the pesticide registration re-assessment procedure in 2006, re-evaluating registered pesticides in a 15-year cycle, with the aim of evolving policies on human health, environmental risks, and evaluation technology.
In the case of changes in practices and practices, ensure that pesticide products are still safe to use in the market
.
China promulgated the "Pesticide Management Regulations" in 1997, which put forward corresponding management requirements for the post-management of pesticides
.
The newly revised "Pesticide Management Regulations" draft stipulates that China's pesticide registration is valid for 5 years, and plant protection agencies monitor the safety and effectiveness of registered pesticides
.
The focus of the post-registration evaluation work is mainly on the safety and effectiveness of the product, which mainly focuses on the safety of agricultural use, the quality and safety of agricultural products, the environmental and ecological safety, and the health and safety of humans and animals to ensure the effectiveness of the product
.
Evaluation methods are mainly system monitoring and special research
.
For example, flubendiamide monitors the safety risk of aquatic ecosystems.
Studies have shown that flubendiamide can be decomposed into more toxic metabolites, which can cause harm to aquatic organisms and threaten the aquatic food chain (especially fish)
.
At the same time, the metabolite is persistent in the environment
.
The U.
S.
Environmental Protection Agency (EPA) announced on March 1, 2016 that it intends to cancel the registration of the pesticide flubendiamide
.
Based on the risks to aquatic invertebrates and the impact on the safety of the aquatic environment, the EPA believes that continued use of flubendiamide will cause a negative impact on the environment, and plans to cancel the registration of flubendiamide products by companies such as Bayer
.
At the 17th plenary meeting of the 8th National Pesticide Registration Review Committee of my country on July 10, 2015, it was proposed to cancel the registration of flubendiamide on rice.

.
According to the environmental behavior test data, ecotoxicological test data, surface water monitoring data, and risk assessment report of flubendiamide, the use of flubendiamide on rice poses an unacceptable risk to invertebrates (large bougainvillea) and has an unacceptable risk to aquatic organisms.
There are great risks to the ecological environment
.
Most of the committee members recognized the results of the test and evaluation, and recommended that applications for the registration of flubendiamide on rice (including applications for renewal) be no longer accepted and approved, and the registration of the use of registered products on rice should be revoked
.
According to Director Zong, the management evaluation of pesticide registration in China will be changed from single evaluation to comprehensive evaluation and comprehensive evaluation; from access management to dual management of access and exit; increase the entry threshold and expand the scope of exit
.
Adjusting thinking, leveraging "prohibition and restriction" to promote the overall improvement of the safety level of preparations Professor Leng Yang from Shanghai Pesticide Research Institute made a report on "adjusting thinking, taking advantage of "prohibition and restriction" to promote the overall improvement of preparation safety level"
.
Professor Leng said that on July 13, 2015, the publication of the "List of Prohibited and Restricted Pesticide Adjuvants" (draft for comments) marked the beginning of the full-component management of pesticides by the Chinese government
.
The Pesticide Inspection Institute drafted and announced the list, aimed at strengthening the management of pesticide additives and ensuring the quality and safety of agricultural products
.
At the meeting, Professor Leng made a detailed analysis of the banned and restricted list
.
In the list, 9 adjuvants are banned, and 75 are restricted and restricted, for a total of 84
.
He conducted an in-depth discussion on the substitution and circumvention of prohibited and restricted additives
.
In particular, Professor Leng reminded manufacturers that some varieties in the banned list are hidden by the use of other components, which should arouse sufficient vigilance and prevention, and focused on introducing 10 channels for hidden entry
.
Among the 84 (groups) of banned and restricted additives, 11 are commonly used solvents, which have the value of selecting and using within the limit, which is the focus of replacement development
.
They are: limited 5%: 7, methanol, triethanolamine, 2-pyrrolidone, N-ethyl-2-pyrrolidone, N-methyl-pyrrolidone, ethyl acrylate, n-ethane
.
Limited 10%: 2, cyclohexanone, xylene
.
Preservatives: 2, benzisothiazolinone (0.
1% limit), isothiazolinone
.
The annual consumption of such common solvents in China is nearly 300,000 tons, accounting for 90% of all solvents, and the involved products account for more than 40% of all registered varieties
.
The majority of the solvent used to configure cream, a small portion for SL, EW, ME, SE and the like
.
Focusing on emulsifiable concentrates and these solvents, and doing a good job of replacement and renewal can drive the substitution of solvents in other dosage forms
.
With the deepening of pesticide management, new restrictions on the selection of organic solvents will be proposed
.
We must see the direction of the country's environmental safety and pesticide safety supervision, consider the improvement of the safety of China's pesticide products from a higher perspective, choose the best plan, and avoid the dilemma of being eliminated after a period of time
.
In the list of banned additives, there are 2 surfactants: nonylphenol and nonylphenol polyoxyethylene ether
.
Nonylphenol is a recognized environmental hormone.
It can mimic estrogen, affect the sexual development of organisms, interfere with the endocrine of organisms, and is toxic to the reproductive system
.
It will promote precocious puberty in girls and lead to infertility in men
.
Nonylphenol polyoxyethylene ether surfactant (NPEO) has the longest history of use and the widest range of use
.
Its disadvantage is slow degradation, and it is widely used as an emulsifier and wetting agent in most formulations of liquid pesticides
.
Professor Leng proposed to use the "forbidden limit" to promote the interactive innovation of solvents and preparations
.
In the past 10 years, the world's pesticide industry has achieved fruitful results in the updating of formulations, the interactive innovation of solvents and emulsifiable concentrates
.
In recent years, the regulation of organic solvents in pesticides by governments of various countries has shifted from banned varieties to content control
.
Such as controlling the VOC (volatile organic compounds) content of pesticides to reduce air pollution
.
The world’s pesticides set the product’s VOC content <20% as a monitoring indicator
.
In order to reduce the solvents used in formulations, the world's pesticide industry vigorously develops new water-based formulations.
Now environmentally friendly pesticide formulations such as EW, SC, WE, ME and WG have become mainstream formulations
.
Since the beginning of this century, two new highlights in the development of the replacement of emulsifiable concentrates have been oriented: one is that microencapsulated preparations break through "closed medication" and enter the field of prevention and treatment; second, the new formulation of emulsion (EG) has entered the stage of industrial development.
Its prospects are widely optimistic
.
Pesticide formulation research and development difficulties, hotspots and product quality improvement Professor Wu Xuemin of China Agricultural University pointed out in the report "Pesticide formulation research and development difficulties, hotspots and product quality improvement" that the effective utilization rate of traditional methods is only 20% to 30%.
The loss rate of the pathway is as high as 50% to 60%, which is not only a waste of economy, but also causes a large area of ​​environmental pollution
.
Therefore, improving the effective utilization rate of pharmaceuticals has become an important issue for preparation processing enterprises
.
Professor Wu proposed to overcome the difficulties of formulation research and development from the following aspects and improve product quality
.
(1) Improve the product quality of solid-liquid and liquid-liquid heterogeneous system preparations
.
The solid-liquid and liquid-liquid dispersion systems are represented by suspending agents and water emulsions, respectively
.
Water emulsions are extremely unstable in thermodynamics and have many interference factors
.
Studying the stability mechanism of different additives is the key to solving the problem of physical stability of pesticide heterogeneous dispersion system
.
(2) The improvement of interface performance and the co-banding of drug targets
.
Adding spray additives to reduce surface tension, improve the adhesion and absorption of effective ingredients on the leaf surface; destroy the surface cells and wax layer of the plant, facilitate the absorption and conduction of the drug in the plant body, and improve the efficacy of the drug
.
(3) Improve the performance of controlled release technology
.
The advantages of controlled release technology are obvious: reduced drift, solidification of liquid pesticides, convenient packaging, storage, transportation, and use, improved utilization of active ingredients of medicines, long duration of validity, time-saving and medicine-saving, and effective reduction of environmental pollution
.
The physical type of controlled release is represented by microcapsules, which is especially suitable for pesticides with small dosages and high control effects such as pheromones and attractants.
It is one of the highest technical content in pesticide formulations and will become the development direction of new pesticide formulations in the future.

.
The size of the particle size determines the stability and release of the microcapsules, and the application of nanotechnology will be an important way to improve the performance of controlled release technology
.
(4) Research and development of labor-saving formulations
.
Labor-saving formulations have developed rapidly at home and abroad in recent years.
The new paddy field labor-saving formulations represented by film spreading oil, floating granules, and U granules save time, labor, and labor for farmers, and have broad development prospects
.
Efforts should be made to strengthen research and investment in this area to promote the development of labor-saving formulations
.
Professor Wu explained in detail the characteristics, processing procedures, and quality indicators of film spreading oil, floating granules, and U granules.
At the same time, he also introduced a new pesticide application technology developed in recent years-the ultra-low volume spray method
.
Originally, after conventional manual spraying, about 50 kilograms of chemical liquid was needed per mu, while low-volume spraying was 1-10 kilograms per mu, and ultra-low-volume spraying could reach 0.
5 kilograms per mu
.
With the drastic reduction in the amount of spraying, the spraying efficiency and control effect have been significantly improved
.
Research and Development Trends of Key Technologies of Dispersible Oil Suspension Concentrates Professor Zhang Zongjian from Sinochem Chemical Science and Technology Research Institute gave a report entitled "Research and Development Trends of Key Technologies of Dispersible Oil Suspension Concentrates"
.
He said that in recent years, pesticide active ingredients and formulations have been developing towards low toxicity and environmental protection, and dispersible oil suspension concentrates have become a hot spot in the development of pesticide formulations in the past 10 years
.
It is a stable suspension of active ingredients dispersed in non-aqueous medium with solid particles, and is generally diluted with water before use
.
Its outstanding advantages are embodied in: first, it is safe and environmentally friendly, easy to store, transport and use; second, it has good medicinal effect, because it uses oil as a dispersion medium, which is conducive to the better adhesion of the medicinal solution to the leaf surface of the plant and rapid expansion and penetration
.
The main disadvantages are: First, the processing is difficult and the formulation stability is poor; second, the cost is relatively high
.
Whether the active ingredients of pesticides are suitable for processing into dispersible oil suspension concentrates, first of all, it is necessary to consider whether the physical and chemical properties of the original drug are suitable for processing into oil suspension concentrates.
Secondly, the obvious synergistic effect of the mixed use of the original drug and oil is the most important consideration.

.
2.
5% Penoxsulam dispersible oil suspension concentrate (Daojie) is a successful example of oil suspension concentrate
.
The processing technology of dispersible oil suspension concentrates involves the screening of product formulations and the production process
.
The focus of formula screening lies in the choice of additives, and the key to the choice of additives lies in the choice of emulsifiers and dispersants
.
The common components of dispersible oil suspension agents, such as active ingredients, oil media, emulsifiers, dispersants, etc.
, and their functions, as well as the influence of the selection of components on its performance, are explained in detail by Professor Zhang
.
Hot issues in the processing of dispersible oil suspension concentrates, such as oil separation problems, grinding or hot storage viscous paste problems, long-term storage agglomeration problems, ternary compound stability problems, etc.
, are also described in the report
.
Professor Zhang also looked forward to the development trend of dispersible oil suspension agents in the report.
He said that because dispersible oil suspension agents conform to the concept of green and environmental protection and high efficiency in the development of formulations, they can meet various spray methods such as flying defenses and have great development.
Potential and Market Prospects: Current Status and Improvement of China's Pesticide Preparation Engineering Technology Director Dai Quan, Director of Preparation Engineering Center of China Pesticide Industry Association, gave a report entitled "The Current Status and Improvement of China's Pesticide Preparation Engineering Technology"
.
According to Director Dai, most of China's pesticide preparation processing companies are facing many engineering and technical problems: a wide range of processing varieties; low production efficiency in workshops; tall but impractical plants; advanced equipment but not systematic and unreasonable configuration; high potential cross-contamination risks
.
The technical level of preparation engineering is divided according to the industry 4.
0 standard that is often said now, and most of them are in the 2.
0-3.
0 stage
.
Director Dai believes that the solution ideas are: starting from the engineering design, formulating the overall project plan, integrating the modern engineering management mode, and improving the overall engineering technology level; reaching the set engineering technology design goal: achieving clean production; energy saving and consumption reduction.
Improve production efficiency; reasonable equipment matching; eliminate substandard products; strictly control pollution sources
.
Continuously improve the living environment of pesticide preparation manufacturers through the improvement of engineering technology, and promote the sustainable development of my country's pesticide industry
.
At the meeting, in addition to the analysis of formulation processing policies and difficult hot issues by the above-mentioned leading experts, Dr.
Zhang Xiaojun from Zhongnong Lihua focused on formulation R&D and process refinement, and researcher Chen Fuliang from the Institute of Plant Protection of the Chinese Academy of Agricultural Sciences discussed pesticide slow-release agents and microspheres.
Research and development, Dr.
Chou Jingyu from the Shenyang Research Institute of Chemical Industry made detailed discussions on seed treatment agents, Qingshan Lvshui Deputy General Manager Deng Defeng, researcher Cui Haixin of the Chinese Academy of Agricultural Sciences, and research and development trends and development trends of nano-pesticides.
, The participants were refreshed, the response was enthusiastic, and the participants benefited a lot
.
It is believed that this conference will greatly promote the exchange and development of my country's preparation processing technology, and greatly improve the level of preparations processing in my country, so as to make China's preparation industry move rapidly in the direction of safety, environmental protection, ecology, and refinement.