my country's orthopedic medical device industry ushered in a high degree of prosperity

Orthopedic medical devices are one of the largest sub-sectors in the entire medical device industry
.
According to public data, the global medical device market sales in 2020 will be 477.
4 billion US dollars, an increase of 4.
6% over the same period of the previous year (the same below); it is expected that the sales will reach 594.
5 billion US dollars by 2024, with a compound annual growth rate from 2018 to 2024.
The rate will reach 5.
6%
.
In terms of segments, the global orthopedic medical device market sales in 2020 will be US$36.
5 billion, accounting for 9% of the total global medical device market sales
.
The total sales of medical devices in China in 2020 was 734.
1 billion yuan, a year-on-year increase of 18.
36%; among them, the orthopaedic implant market size was 36 billion yuan, a year-on-year increase of 16.
44%, accounting for 4.
90% of the total medical device scale, much lower than that of orthopedic devices.
The proportion of the global medical device market, the orthopedic medical device industry has broad prospects for development
.
There are many sub-tracks The medical device industry can be divided into four categories: high-value medical consumables, low-value medical consumables, medical equipment, and in vitro diagnosis (IVD)
.
According to different uses, high-value medical consumables can be subdivided into orthopedic implantation, vascular intervention, neurosurgery, ophthalmology, stomatology, blood purification, non-vascular intervention, electrophysiology and pacemaker, and others
.
Orthopedic medical devices usually refer to clinical orthopedic medical materials used for human bone replacement, support, repair, and filling, which can completely or partially replace joints, bones, cartilage or musculoskeletal systems, including shoulders, elbows, hips, knees, and spine.
etc.

_ Due to the high value of this category of products and an important impact on human life and health, many links such as production and use must be strictly controlled, and are generally classified as high-value medical consumables
.
Orthopedic implant products can be divided into trauma, spine, joint and others according to different parts of use
.
The market share of the first three accounts for more than 80% of the orthopaedic implant market, and their products mainly include bone joint implants and joint implants, such as bone plates, bone screws, intramedullary nails, spinal internal fixation implants, artificial joints, etc.

.
Rapid market growth China's orthopedic consumables industry experienced a difficult development process before the 1980s, which laid a certain foundation for the development of the orthopedic medical device industry
.
With the rapid improvement of national economic strength and scientific research strength, domestic medical device enterprises have developed rapidly
.
After entering the 21st century, many multinational enterprises have entered the Chinese market
.
In the continuous learning and competition, domestic orthopedic medical device companies have made great progress in all aspects
.
Under the background of China's huge population base and the accelerating process of social aging, the market size of orthopedic implants has grown from 11.
7 billion yuan in 2013 to 36 billion yuan in 2020, with a compound annual growth rate of 17.
14%.
It is expected to reach 2023.
The annual market size will exceed 57 billion yuan (see chart for details)
.
Today, China has become the second largest orthopaedic implant market in the world.
With the continuous increase in the incidence of bone diseases (such as osteoporosis, intervertebral disc herniation, femoral neck fracture, etc.
) in the elderly, coupled with people's demand for health It is expected that the growth rate of China's orthopaedic implant market will be much higher than that of the world
.
R&D and innovation breakthroughs In terms of technology, spinal implants will usher in new developments
.
Due to factors such as high R&D thresholds, complex production processes, difficult market access, and strict quality supervision, the early domestic artificial orthopaedic spine and joint implant manufacturers developed relatively slowly
.
In recent years, with the improvement of the domestic artificial joint implant development level, the improvement of the manufacturing process and the quality control level, the local enterprises have occupied more markets with the advantages of high quality and low price
.
At present, the development of spine and orthopedics is relatively mature, new technologies and new therapies are still emerging, and the means of disease diagnosis, treatment and evaluation are gradually improving
.
Up to now, the mainstream products of spinal implants are mainly divided into two categories: one is a spinal internal fixation system composed of bone plates, fixation rods, screws, etc.
alone or in combination, and the other is an intervertebral cage.

.
With the continuing education of doctors, academic promotion and the development of imaging technology, more and more secondary and tertiary hospitals are able to carry out spinal surgery and even minimally invasive surgery
.
In the future, spinal surgery will continue to develop towards precision, minimally invasive and intelligent development
.
In terms of safety, infection, rejection, and release of harmful metal ions are major problems faced by the development of implant medical devices, which have not been effectively solved worldwide
.
Patient infection is one of the most serious early clinical complications after most orthopaedic implant operations, resulting in intractable, painful, time-consuming, costly, disability and even death
.
The rejection reaction caused by the implant is more than a few months after the operation, and the clinical manifestation is local redness, swelling and pain, often accompanied by infection
.
The release of harmful metal ions mostly occurs several years after surgery, which may lead to osteoporosis, rash, cardiovascular disease, nervous system disease, and cancer.
For example, the carcinogenic incubation period of metal element nickel is 23 to 27 years
.
The research and application of new materials is expected to promote breakthroughs in the safety of implant medical devices
.
For example, calcium phosphate ceramics are an important class of bone substitute materials, of which hydroxyapatite (HAP) and tricalcium phosphate (TCP) ceramics are the most studied
.
HAP has a lamellar microcrystalline structure, which is similar to human and vertebrate bones and teeth in composition and structure, and has good biocompatibility
.
For example, the HAP coating of composite osteoinductive biomaterials can effectively prevent the formation of bacterial biofilms, reduce the risk of postoperative infection in orthopaedic/dental implants, reduce bacterial drug resistance, and promote the biological healing function of bone and soft tissue.
, shorten the postoperative recovery time and the patient's hospitalization time, reduce the cost of surgical treatment, reduce the physical, psychological and economic burden of the patient, and effectively save medical resources
.
Tantalum is a rare precious metal with physical and chemical properties such as acid resistance, alkali resistance, corrosion resistance and high temperature resistance
.
Due to its good biocompatibility, tantalum is recommended by international clinical experts as an implant material
.
However, the properties of high hardness and high melting point (up to 2996°C) make tantalum difficult to process, making it difficult to popularize in medical device production and clinical applications, and it has also become one of the research directions for orthopaedic medical device materials
.
In addition, biomedical inorganic non-metallic bone repair materials have many advantages, such as wide source of raw materials, easy preparation, low cost, good chemical stability, biocompatibility and biological activity, and controllable structure and chemical composition.
Repair materials have a large market space
.
(Author Unit: Flint Creation)