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Scientists are using in vitro (in a Petri dish) skeletal muscle engineering to better understand the complex genetic and environmental factors
In AIP's Biophysical Review, researchers from The Georgia Institute of Technology and Emory University School of Medicine describe how skeletal muscle engineering has made remarkable progress over the past few decades
Co-author Christina Sheng said: "We can use skeletal muscle grown in the lab to capture and study the characteristics of diabetic diseases
Exoskeletal muscle models have also led to personalized medicine, in which individual patients' muscles can be grown, studied and tested to determine if new drugs work for
In general, muscle stem cells are collected, increased in number, and sown
To mimic diabetes, the researchers treated lab-grown skeletal muscle with excess sugar, insulin, fat, or cell therapy that promotes inflammation, and studied how these factors affect skeletal muscle health
"Our bio-hybridization system laboratory grows and exercises skeletal muscle to study healthy protein factors secreted by muscles during exercise," said
"Most of the skeletal muscle in vitro models used for exercise and diabetes research are two-dimensional
Journal Reference:
Christina Y.
