Multiple articles to interpret recent new achievements in the field of dementia research!

!-- webeditor: page title" -- In this article, a number of articles have been compiled to share recent scientific achievements in the field of dementia research! Photo Source: CC0 Public Domain 1 The Lancet: By modifying or improving 12 risk factors or preventing or mitigating 40% of global dementia cases! doi:10.1016/S0140-6736 (20) 30367-6 According to the World Alzheimer's 2018 Report, one dementia patient is born globally every three seconds.
currently has at least 50 million people with dementia worldwide, and that number is expected to reach 152 million by 2050, of which about 60-70% are Alzheimer's disease (AD).
There are currently about 10 million people with Alzheimer's disease in China, and the number of people with Alzheimer's disease in China is expected to exceed 40 million by 2050;
In recent years, as mortality among young people has declined, including among older people with dementia, the incidence of age-related dementia has begun to decline in many developed countries, perhaps directly related to changes in education, nutrition, health care and lifestyle.
Overall, there is growing evidence to support nine potentially modifiable risk factors simulated by the Lancet Commission for dementia prevention, intervention and care in 2017, including low levels of education, high blood pressure, hearing impairment, smoking, obesity, depression, lack of physical activity, diabetes and low social contact, a paper published recently in the international journal The Lancet entitled "Dementia, In a review of the 2020 report of the Lancet Commission, scientists from University College London and others added three new and well-established risk factors, including excessive drinking, traumatic brain injury and air pollution, to their nine previous modifiable risk factors for dementia; Incorporating these three risk factors into the updated dementia prevention life cycle model of 12 risk factors, the researchers said it was important to prevent dementia, especially in low- or middle-income countries (LMIC), by focusing on the 12 modifiable risk factors mentioned above or preventing or slowing the onset of dementia globally.
type 2 diabetes is associated with an increased risk of cancer and dementia? News read: A disease that breeds disease: why is type 2 diabetes linked to increased risk of cancer and dementia? In Australia, more than 1.1 million people currently have type 2 diabetes.
many of the potential complications associated with diabetes mean that a 45-year-old diagnosed with type 2 diabetes will live an average of six years less than someone who does not have type 2 diabetes.
, Rachel Climie and Jonathan Shaw, among others, published a report that gathered the latest evidence on the health consequences of type 2 diabetes.
addition to demonstrating the link between well-known complications such as diabetes and heart disease risk, their report highlights new evidence linking type 2 diabetes to an increased risk of cancer and dementia.
type 2 diabetes usually occurs after the age of 40, usually because the pancreas does not produce enough insulin hormones and the cells in the body do not respond adequately to insulin.
insulin is a key regulator of blood sugar, which causes blood sugar levels to rise.
( 3) Int J Epidemiol: Obesity or a direct link to an increased risk of dementia in the population Doi:10.1093/ije/dyaa099 A recent study published in the international journal International Journal of TheOlogy by scientists at University College London and others found that obesity or increased risk of dementia in individuals after 15 years played a key role in reducing the risk of dementia in the body.
this paper suggests that obese individuals may be at a 31 percent increased risk of dementia later in life, compared to individuals with a normal range of body mass index (BMI), with women at a higher risk.
researcher Dr Dolina Cadar said the findings may provide new evidence that obesity is important for indicating dementia risk; individual BMI and waist circumference states should probably be monitored to effectively avoid metabolic abnormalities in the body, so they recommend that people adopt healthy and balanced eating patterns (such as Mediterranean diet patterns), proper physical activity and reduced alcohol intake throughout adulthood to lower body weight to normal levels.
4: Watch out! Excessive drinking can lead to dementia-like diseases! News read: Too much alcohol can cause similar effects to dementia - and the two are often confused According to a recent survey, 21% of people in the UK drink more alcohol than before the pandemic.
comes after reports that alcohol sales rose 31 per cent at the start of social estrangement.
as traditional social gatherings were shelved, virtual bar quizzes and online gatherings quickly replaced them.
twitter hashtags such as "Quarantini" and "Ferlough Merlot" show that for many people, drinking alcohol is a key factor in the pandemic experience.
!--/ewebeditor:page--!--ewebeditor:page-title"--some people may use alcohol to relieve anxiety, stress, or even fill the time they usually spend on fitness or socializing.
whatever the cause, although most drinkers are aware of the effects of alcohol on the liver or waistline, many do not realize that excessive (and persistent) drinking can cause long-term damage to the brain.
-related brain injury (Alcohol-related brain damage, ARBD) is a group of diseases that are not fully relevant and involve changes in the structure and function of the brain.
can impair memory, thinking, planning, and reasoning, and lead to changes in personality and behavior.
: Brain inflammation may be closely related to the development of multiple types of dementia Doi:10.1093/brain/awaa033 A recent study published in the international journal Brain found that brain inflammation may be more widely associated with dementia than previously thought; the findings may help researchers develop new treatments for multiple types of dementia.
Inflammation is usually the body's response to injury and stress, such as redness and swelling associated with injury or infection; however, inflammation in the brain (neuroinformation) is now thought to be directly related to a variety of diseases, such as depression, psychosis and multiple sclerosis, and recently researchers have found that neuro-inflammation is directly related to the onset of Alzheimer's disease.
picture source: Gill Livingston et al. The Lancet doi:10.1016/S0140-6736 (20) 30367-6. Highly processed meats, starchy foods, snacks, dietary combinations that significantly increase the risk of dementia, and a varied diet significantly reduces the risk! doi:10.1212/WNL.00000000009399 Numerous studies have shown that diets such as those rich in leafy greens, nuts, whole grains and fish can effectively reduce the body's risk of dementia, and most studies focus on the effects of the number and frequency of diets on the health of the body; The pattern may be directly related to the risk of developing dementia; in a recent study published in the international journal Neurology entitled "Using network science tools to identify novel diet patterns in prodromal dementia", scientists from institutions such as the University of Bordeaux used a technique called "network science" to simulate the relationship between complex dietary relationships and people's risk of developing dementia. People who regularly eat foods such as highly processed meats, starchy foods (potatoes, etc.) and snacks (cookies, cakes, etc.) are at higher risk of developing dementia later in life than those who eat multiple types of healthy foods on a daily basis.
The researchers speculate that food intake in the population is a special system that can be conceptualized as a network to simulate the consumption patterns of human food items, a web-based scientific approach that can reveal the complexity and nonlinearity of daily eating patterns, thus helping the researchers to reveal that food consumption patterns tend to be higher in the population compared to the population with dementia; The 78-year-old dementia patient and 418 non-dementia patients with age, gender and education matched the former; during the 12-year follow-up process, the researchers determined dementia events based on participants' baseline food frequency questionnaires, and for each case, they randomly selected 2 control individuals among groups at risk of the age at which the case was diagnosed, and matched the age, sex, education and survey seasons of the dietary assessment. Using interactive information, a measure that detects nonlinear relationships, the researchers deduced the food networks of the study and control group participants, and compared the differences in food intake patterns between the two groups.
: "7 Alzheimer's: Shock! Repeated negative thinking is associated with an increased risk of dementia! A new study led by Doi:10.1002/alz.12116 University College London has found that long-term negative thinking patterns may increase the risk of Alzheimer's disease.
in a study of people over 55 who were over 55 in a study published in the journal Alzheimer's, researchers found that "repetitive negative thinking, RNT) was associated with subsequent cognitive decline and harmful brain protein deposits associated with Alzheimer's disease."
researchers say it's time to further study RNT as a potential risk factor for dementia, and psychological tools such as mindaction or meditation should be studied to see if they can reduce the risk of dementia.
researchers say depression and anxiety in middle age and old age are known to be risk factors for dementia.
, we found that certain patterns of thinking associated with depression and anxiety may be a potential cause of dementia in people with disabilities.
with other studies linking depression and anxiety to dementia risk, we expect long-term negative thinking patterns to increase the risk of dementia.
we don't see evidence that short-term setbacks increase a person's risk of dementia.
we hope our findings can be used to develop intervention strategies to reduce the risk of dementia by helping people reduce their negative thinking patterns.
: Open Biol: Antioxidant cocktails are key to preventing Alzheimer's disease: 10.1098/rsob.200084 A study by the University of Western Australia (UWA) found that a diet rich in nutrients and antioxidants may prevent or even reverse the effects of Alzheimer's disease.
study, published in the journal Open Biology, found that increasing the dose of antioxidants was more beneficial in preventing the debilitating disease than any other treatment currently available.
!--/ewebeditor:page--!--ewebeditor:page"--more than 70 percent of deaths worldwide are caused by chronic defed diseases such as Alzheimer's disease, oxidative stress, chronic metabolic acidosis, and free agents in the body play a key role in the aging process.
study showed that antioxidants react with free agents in the body, making them harmless.
Gerald Veurink, who conducted the study while working at the UWA School of Medicine, examined a range of antioxidants to find out which are most effective at protecting neurons in the body's nervous system.
: Blood testing helps accurately diagnose Alzheimer's doi:10.1038/s41591-020-0762-2 A new blood test technique could help detect early-stage Alzheimer's disease, according to a recent study led by the University of California, San Francisco.
the study, researchers measured blood levels of tau 181 (pTau181), a brain protein that is often found in brain neurons entangled in Alzheimer's patients.
found that people with Alzheimer's were 3.5 times more likely to have pTau181 than their healthy peers.
, pTau181 levels were matched to normal in patients with alzheimer's disease , which is often misdiagnosed as Alzheimer's disease.