Multi-mode chromatography fillers have a larger sample load and reduce costs

The advantage of multi-mode chromatography fillers to tolerate high salt loading is that when the sample is at a high salt ion concentration, we can directly load the sample without desalting, reducing the experimental steps and still obtaining a good load
.

In addition, because it contains a variety of different forces, has better selectivity than the average weak cation, CaptoMMCImpRes also has a very good effect
in the fine purification process of monoclonal antibody and some antibody fragments.

Performance of multi-mode chromatography filler: 1.
Double-layer structure design, with flow through mode to process more than 700KD of macromolecules, process optimization is easier, more convenient for linear amplification
.

2.
The improved MaXtar scaffolding has stronger rigidity, so it can achieve higher process flow rates and improve process efficiency
at lower back pressures.

3.
Compared with the traditional gel filtration chromatography, it has a larger sample load and reduces costs
.

It has different selectivity
compared to conventional ion exchangers.

1.
High dynamic binding load under high conductivity can improve productivity
.

2.
High volume flux can shorten the processing time
.

3.
Smaller unit operation enables cost-effective processing and reduces investment
.

4.
Fillers meet industrial needs
for supply security, stable performance and regulatory support.

Multi-mode chromatography filler is different from the traditional chromatography medium, it is composed of two different structures: the shell is a porous passivation layer, to ensure that macromolecules above 700KD will not enter the pores, directly through the outside of the water flow; The core is a spherical core coupled with octalamine groups (both hydrophobic and positive charge adsorption), which binds to a large extent to impurities
such as host proteins and nucleic acids.

This chromatography medium can be well used for the isolation and purification of a variety of macromolecular biological samples, such as viruses and virus-like particles
.