mSystems: Discover natural antibiotics that kill bacteria efficiently! or a potential new weapon against superbugs.

, June 18, 2020 /PRNewswire/
Researchers at the University of Melbourne are looking for ways to beat dangerous super-
bacteria
with "resistant"antibioticsthat could help us fight the complications of the coronavirus (COVID-19)asbacteriaevolve, they develop strategies to destroyantibiotic, turning them into "super-
bacterial" that can resist most existing treatments and lead to potentially fatal infectionsMelbourne's team has shown that a newly discovered naturalantibioticteixobactin can be effective in treatingbacterialung diseases, such as tuberculosis and diseases commonly associated with COVID-19their work could pave the way for a new generation ofto treat particularly stubborn super
bacteriaphoto source: Discovered in 2015 by a team led by Professor Kim Lewis of Northeastern University in BostonHis company is developing it as a human therapynew study at the University of Melbourne, published in mSystems, explains for the first time the relationship between teixobactin and the super
bacteriaStaphylococcus aureus, also known as MRSAmethicillin-resistant Staphylococcus aureus is one of several bacteria that are difficult to treat in humans, especially virus-followingbacterialinfections such as COVID-19 chest infections and influenzateam of university of Melbourne anti-infective researcher Dr Maytham Hussein and associate professor Tony Velkov synthesized one aspect of teixobactin, resulting in a compound that has excellent efficacy against MRSADr said there was no way to stop bacteria like MSRA resistant to antibiotics because it was part of its evolution This makes the fight extremely challenging "The increase in multidrug-resistant bacteria has become inevitable," Dr Hussein said "These bacteria can cause many deadly infections, especially in patients with low immunocompromised function, such as diabetes
or cancer patients, or even older people with flu-
-on-the-flu infections." team at the University of Melbourne for the first time found that teixobactin significantly inhibited resistance to vancomycin-based antibiotics, which are recommended for complex skin infections, blood flow infections, endocarditis, bone and joint infections, and meningitis caused by MRSA Associate Professor Velkov says this will greatly facilitate preclinical development of teixobactin Associate Professor velkov, , said: "Bacteria usually develop resistance within 48 hours of exposure to antibiotics "The bacteria did not become resistant to the compound for 48 hours " these new results will open the door to the development of new antimicrobial drugs to treat a variety of drug-resistant Gram-positive infections -- thick cell walls caused by certain types of bacteria
bacteria (BioValleyBioon.com) References: Maytham Hussein et al.
The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphyloccus aureus: an Untabat Metabolomics Study , mSystems (2020) DOI: 10.1128/mSystems.00077-20