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In the context of the global pandemic of the new crown epidemic, the mRNA vaccine became famous
Recently, the research group of Prof.
1.
2.
2.
3.
1.
It can detect 200 bp single free DNA with ultra-high sensitivity, and realize accurate quantitative analysis of EVs internal nucleic acid, surface nucleic acid, and free nucleic acid
.
2.
The detection range covers the entire size range of exosomes (40-200nm), and the overall exosome nucleic acid loading distribution is analyzed
.
3.
Determine the type and content of EVs nucleic acid at the single particle level to determine the nucleic acid encapsulation efficiency and content
.
4.
Optimize nucleic acid loading conditions and purification methods to obtain high-quality exosomal nucleic acid drugs
.
References:
1.
Haisheng Liu etal.
Analysis of extracellular vesicle DNA at the single-vesicle level by nano-flow cytometry.
Journal of Extracellular Vesicles, 2022, e12206.
2.
Thomas C.
Roberts et al.
Advances inoligonucleotide drug delivery.
Nature reviews Drug Discovery (2020), 19, pages 673–694 3.
Kulkarni, JA et al.
“The Current Landscape of Nucleic Acid Therapeutics.
” Nature Nanotechnology, 2021, 16(841): 630-643
This study provides direct and conclusive experimental evidence for in-depth understanding of the relationship between DNA and EVs, provides theoretical experience and basis for the loading of nucleic acid in exosomes in the later stage, and is expected to promote the research and development of exosome nucleic acid drugs
1.
It can detect 200 bp single free DNA with ultra-high sensitivity, and realize accurate quantitative analysis of EVs internal nucleic acid, surface nucleic acid, and free nucleic acid
.
2.
The detection range covers the entire size range of exosomes (40-200nm), and the overall exosome nucleic acid loading distribution is analyzed
.
3.
Determine the type and content of EVs nucleic acid at the single particle level to determine the nucleic acid encapsulation efficiency and content
.
4.
Optimize nucleic acid loading conditions and purification methods to obtain high-quality exosomal nucleic acid drugs
.
References:
1.
Haisheng Liu etal.
Analysis of extracellular vesicle DNA at the single-vesicle level by nano-flow cytometry.
Journal of Extracellular Vesicles, 2022, e12206.
2.
Thomas C.
Roberts et al.
Advances inoligonucleotide drug delivery.
Nature reviews Drug Discovery (2020), 19, pages 673–694 3.
Kulkarni, JA et al.
“The Current Landscape of Nucleic Acid Therapeutics.
” Nature Nanotechnology, 2021, 16(841): 630-643
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