MRI finds post-traumatic brain tissue shrinkage rate triples

Ref:Cole JH,et al.Brain2018 Mar 1;141 (3): 822-836doi: 10.1093/brain/awx354."cranial brain trauma can cause brain atrophy, clinically characterized by rapid degeneration of nerve functionPrevious animal models and human brain imaging studies have reported the atrophy of brain tissue after traumatic brain trauma, but no quantitative measurements have been carried outRecently, James HCole of the Cognitive and Clinical Neuroimaging Laboratory at Hamsmith Hospital in London, Ukalt, and others used the skull MRI image and jacobian determinant algorithm (jacobian determinant metric) to track brain tissue atrophy in patients with moderate and heavy brain trauma, published in the March 2018 issue of Brainthe study had three main characteristics: the establishment of a matching normal healthy person control group to conduct MRI follow-up follow-up, follow-up period of 1 year, significantly longer than the previous lyson published 2-3 months follow-up time, based on body beam tracking and Jacobian determinant algorithm, accurate calculationstudy included 61 patients with moderate and heavy-duty brain trauma, with an average age of 41.6 to 12.8, with a ratio of 49:12 for men and womenThe average time for head MRI follow-up in patients with brain trauma was 11.7 months, while the average time of head MRI follow-up in 32 healthy patients in the control group was 12.7 monthsThere was no statistical difference in age, gender, and follow-up time between the two groupsMRI follow-up results showed that brain trauma patients lost 1.55% of gray mass, 1.49% loss of white matter, and 1.51% reduction in total brain tissue, while normal control of healthy people in the same period of time reduced gray matter by 0.55%, white matter increased by 0.26%, and total brain tissue decreased by only 0.22%As a result, the rate of brain atrophy increased threefold in patients with brain trauma compared to normal people Further studies showed that the gray matter of the bilateral frontal, temporal, pillow and island lobes in patients with cranial brain trauma, as well as a number of subcutaneous cell nuclear groups, including the hypothalamus, amygdala, hippocampus and tailal nuclei, and cerebellum, showed significant volume reduction, while the brain ventricular region of the cerebral cortex was more pronounced than the brain-back region atrophy At the same time, the vast majority of the brain white matter, that is, 85.4% of the body beam, also significantly atrophy (Figures 1, 2) finally, the authors analyzed the relationship between brain atrophy and brain function loss By combining quantitative data and neuropsychological scale assessment of brain atrophy, it was found that those with severe cerebral atrophy scored lower on a number of neuropsychological assessment projects The researchers believe that after a smooth period of acute period, patients with moderate and heavy cranial brain trauma lack effective rehabilitation and treatment, which is a possible mechanism of neuropathic degeneration of cerebral trauma The study showed that the degree of atrophy of imaging-suggested brain tissue could be used as an indicator to evaluate the effect of rehabilitation treatment Previous methods and drugs for the treatment of degenerative neurodegenerative diseases, such as Alzheimer's disease and Huntington's disease, can be used in the treatment of patients with cranial brain trauma Figure 1 Comparison of brain tissue atrophy in normal control groups and patients with cranial brain trauma Figure 2 The difference between the brain grooves and the degree of brain retrophy in patients with cranial brain trauma is more pronounced (
sun Yirui, of Huashan Hospital affiliated with Fudan University, professor Wang Zhiqiu , of Huashan Hospital, Fudan University, reviewed, editor-in-chief of "Outside The God Information" and professor of The of Fudan University) related links