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Spinocerebellar ataxia type 3 (SCA3) is the most common dominantly inherited ataxia, resulting in severe disability and premature death
.
While there is currently no curative treatment, several methods to reduce the mutant protein have been developed, and pilot trials appear to be just around the corner
Nonetheless, symptomatic treatment and patient counseling will remain the cornerstone of SCA3 patient care
.
Although significant progress has been made in understanding the natural history of SCA3, the observed high variability in disease severity, progression, and age of onset can only be partially explained by extended allele repeat lengths
This suggests that other genetic or environmental factors, including life>
.
To date, the role of life>
In this multicenter prospective observational study, Holger Hengel et al.
of the University of Tübingen assessed life>
They found that patients with SCA3 were less active and drank less alcohol than controls
.
Less physical activity and alcohol abstinence were associated with more severe disease, but not with disease progression rate or age at onset
.
Smoking, BMI, or physical therapy were not associated with disease parameters
Less physical activity and alcohol abstinence were associated with more severe disease, but not disease progression rate or age at onset
The significance of the study is its findings: Differences in life>
.
No association was found between life>
Differences in life>
Original source:
Hengel H, Martus P, Faber J, et al.
Characterization of Life>
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